{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:30:06Z","timestamp":1777570206250,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000297","name":"Royal College of Surgeons of England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>There is currently conflicting level 1 evidence in the use of long\u2010term antibiotics for chronic rhinosinusitis without nasal polyps. The primary aim of this feasibility study was to optimise future randomised trial design by assessing recruitment and retention of patients alongside providing preliminary data on symptomatic control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, multicentre feasibility (cohort) study with all patients receiving macrolide therapy for 12 weeks and a further subsequent 12\u2010week follow\u2010up. Participants received a 12\u2010week course of clarithromycin 250 mg alongside twice daily topical mometasone and nasal douching. Primary outcomes focused on recruitment, retention and compliance. Clinical and quality\u2010of\u2010life outcomes measures were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Patients were prospectively recruited from six <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> outpatient clinics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Adult patients with chronic rhinosinusitis without nasal polyps and no prior endoscopic sinus surgery underwent baseline assessment and then follow\u2010up at 3 and 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Six\u2010month recruitment and retention data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 13 months, 55 adults were recruited from five centres. Four patients declined participation. 75% of patients were retained within the study. Dropouts included one medication contraindication, three unable to tolerate medication and 10 not attending full follow\u2010up. Sino Nasal Outcome Test\u201022 and endoscopic scores showed statistically significant improvement. No other clinical or quality\u2010of\u2010life assessment improvements were seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Retention and recruitment to a trial using long\u2010term clarithromycin to treat chronic rhinosinusitis without nasal polyps is achievable and this data will support a future randomised controlled trial. The study provides vital insight into trial design, thus informing <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> research networks and rhinology researchers internationally.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12685","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T19:33:39Z","timestamp":1464204819000},"page":"131-138","source":"Crossref","is-referenced-by-count":6,"title":["The value of a feasibility study into long\u2010term macrolide therapy in chronic rhinosinusitis"],"prefix":"10.1111","volume":"42","author":[{"given":"J.","family":"Bewick","sequence":"first","affiliation":[{"name":"James Paget University Hospital Great Yarmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Carrie","sequence":"additional","affiliation":[{"name":"Freeman Hospital Newcastle UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Guys &amp; St Thomas\u2019 Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sama","sequence":"additional","affiliation":[{"name":"Queens Medical Centre Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Sunkaraneni","sequence":"additional","affiliation":[{"name":"Royal Surrey County Hospital Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Woods","sequence":"additional","affiliation":[{"name":"James Paget University Hospital Great Yarmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Morris","sequence":"additional","affiliation":[{"name":"University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Erskine","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia Norwich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-3236","authenticated-orcid":false,"given":"C.M.","family":"Philpott","sequence":"additional","affiliation":[{"name":"James Paget University Hospital Great Yarmouth UK"},{"name":"Norwich Medical School University of East Anglia Norwich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"23","author":"Fokkens W.J.","year":"2012","journal-title":"Rhinol. 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