{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:35:52Z","timestamp":1790166952756,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Objective<\/jats:title>\n \n To validate the Airway\u2013Dyspnoea\u2013Voice\u2013Swallow (\n ADVS<\/jats:styled-content>\n ) instrument as a disease\u2010specific Patient\u2010Reported Outcome Measure in paediatric laryngotracheal stenosis.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective observational study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n A quaternary referral centre for complex airway disease.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Forty\u2010eight patients (30 males) with a mean age of 49 \u00b1 49 months who underwent laryngotracheal surgery or microlaryngoscopy and bronchoscopy (\n MLB<\/jats:styled-content>\n ) following laryngotracheal surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n \n Airway\u2013Dyspnoea\u2013Voice\u2013Swallow summary scale and Patient\u2010Reported Outcome Measure (\n PROM<\/jats:styled-content>\n ), Paediatric Quality of Life (Peds\n QL<\/jats:styled-content>\n ) scale, Paediatric Voice Handicap Index (\n pVHI<\/jats:styled-content>\n ) and Lansky performance scale were administered to patients before and 6\u20138 weeks following airway examination\/surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Most patients (73%) had intubation\u2010related subglottic stenosis, and 60% of patients had prior airway treatments. The majority of patients (77%) had more than one major chronic morbidity, and the commonest procedures were diagnostic\n MLB<\/jats:styled-content>\n (49%), followed by airway dilation (29%). Cronbach\u2010\n \u03b1<\/jats:italic>\n value for the\n ADVS PROM<\/jats:styled-content>\n was 0.71 overall and 0.85, 0.86 and 0.64 for the dyspnoea, voice and swallow domains, respectively. Rank correlations between Dyspnoea, Voice and Swallow summary scale and\n PROM<\/jats:styled-content>\n scores were 0.83, 0.71 and 0.81, respectively (\n P<\/jats:italic>\n < 0.0001). For those patients undergoing diagnostic\n MLB<\/jats:styled-content>\n , pre\u2010 and post\u2010examination scores were highly correlated (intraclass correlations >0.75). There was a significant rank correlation between\n ADVS PROM<\/jats:styled-content>\n score and Lansky performance score (\n r<\/jats:italic>\n = \u22120.68;\n P<\/jats:italic>\n < 0.0001). There were significant correlations between\n PROM<\/jats:styled-content>\n score and Peds\n QL<\/jats:styled-content>\n (\n r<\/jats:italic>\n = \u22120.57;\n P<\/jats:italic>\n < 0.0001) and between voice domain of the\n PROM<\/jats:styled-content>\n and\n pVHI<\/jats:styled-content>\n (\n r<\/jats:italic>\n = 0.78;\n P<\/jats:italic>\n < 0.0001). There were strong correlations between Myer\u2013Cotton stenosis severity and dyspnoea scale and\n PROM<\/jats:styled-content>\n score (\n r<\/jats:italic>\n = 0.68;\n P<\/jats:italic>\n < 0.0001). There were significant differences in voice and swallow\n ADVS<\/jats:styled-content>\n scales and\n PROM<\/jats:styled-content>\n scores between patients with and without concomitant laryngeal\/oesophageal pathology. Patient age and presence of high dyspnoea and swallowing\n PROM<\/jats:styled-content>\n scores were independently associated with poorer quality of life and performance status.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These series of observations validate the\n ADVS<\/jats:styled-content>\n instrument as a disease\u2010specific outcome measure for paediatric laryngotracheal stenosis. Dyspnoea and swallowing dysfunction appear to have the greatest impact on quality of life. More widespread adoption of the\n ADVS<\/jats:styled-content>\n instrument could help create a shared language for outcomes communication and benchmarking for children with this complex condition.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.12729","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T02:36:41Z","timestamp":1471660601000},"page":"283-294","source":"Crossref","is-referenced-by-count":16,"title":["Validation of the Airway\u2013Dyspnoea\u2013Voice\u2013Swallow (ADVS) scale and Patient\u2010Reported Outcome Measure (PROM) as disease\u2010specific instruments in paediatric laryngotracheal stenosis"],"prefix":"10.1111","volume":"42","author":[{"given":"S.A.R.","family":"Nouraei","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Great Ormond Street Hospital London UK"},{"name":"Department of Ear Nose and Throat Surgery Auckland City Hospital Auckland New Zealand"},{"name":"Academic Department of Surgery University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Makmur","sequence":"additional","affiliation":[{"name":"The Medical School University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Ear Nose and Throat Surgery Auckland City Hospital Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.","family":"Butler","sequence":"additional","affiliation":[{"name":"Academic Department of Surgery University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Nandi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.04.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0030-6665(20)30497-7","article-title":"Diagnosis and management of pediatric tracheal stenosis","volume":"28","author":"Rimell F.L.","year":"1995","journal-title":"Otolaryngol. Clin. North Am."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2006.10.004"},{"key":"e_1_2_9_5_1","first-page":"Doc09","article-title":"Pathologies of the larynx and trachea in childhood","volume":"13","author":"Sittel C.","year":"2014","journal-title":"GMS Curr. Top. Otorhinolaryngol. Head Neck Surg."},{"key":"e_1_2_9_6_1","volume-title":"Laryngeal and Tracheobronchial Stenosis","author":"Sandhu G.S.","year":"2015"},{"key":"e_1_2_9_7_1","first-page":"53","volume-title":"Laryngeal and Tracheobronchial Stenosis","author":"Nouraei S.M.","year":"2015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-002-0526-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111001204"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180310574"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2010.03.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-150687"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25482"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2007.01474.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2011.02298.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300410"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980315)82:6<1184::AID-CNCR25>3.0.CO;2-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.09.004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871001)60:7<1651::AID-CNCR2820600738>3.0.CO;2-J"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24373"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12595"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.05.008"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60737-5"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01969.x"},{"key":"e_1_2_9_25_1","first-page":"2025","article-title":"Minimal clinically important difference, low disease activity state, and patient acceptable symptom state: methodological issues","volume":"32","author":"Tubach F.","year":"2005","journal-title":"J. Rheumatol."},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.079798"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12729","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:35:26Z","timestamp":1696376126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,8]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/coa.12729"],"URL":"https:\/\/doi.org\/10.1111\/coa.12729","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,8]]}}}