{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:28:11Z","timestamp":1790612891154,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"\n Background<\/jats:title>\n \n Diagnosis and management of recurrent or residual cholesteatoma can be problematic. Diffusion\u2010weighted imaging magnetic resonance imaging (\n MRI<\/jats:styled-content>\n ) sequences have been used for follow\u2010up of such lesions. More recent non\u2010echoplanar imaging (non\u2010\n EPI<\/jats:styled-content>\n ) sequences are thought to be superior to older echoplanar imaging (\n EPI<\/jats:styled-content>\n ) sequences.\n <\/jats:p>\n <\/jats:sec>\n \n Objective of review<\/jats:title>\n Evaluate whether diffusion\u2010weighted magnetic resonance imaging is useful in the diagnosis of recurrent or residual cholesteatoma.<\/jats:p>\n <\/jats:sec>\n \n Type of review<\/jats:title>\n Systematic review and meta\u2010analysis.<\/jats:p>\n <\/jats:sec>\n \n Search strategy<\/jats:title>\n \n MEDLINE<\/jats:styled-content>\n ,\n EMBASE<\/jats:styled-content>\n ,\n CINAHL<\/jats:styled-content>\n , Web of Science and the Cochrane Database were searched, with no limits on date or language.\n <\/jats:p>\n <\/jats:sec>\n \n Study Selection<\/jats:title>\n Adults or children who had previously undergone tympanomastoid surgery by any method with confirmation of recurrence\/residual disease by second\u2010look\/revision surgery.<\/jats:p>\n <\/jats:sec>\n \n Evaluation methods<\/jats:title>\n Two reviewers independently reviewed studies. Data extracted on 11 domains and rechecked.<\/jats:p>\n <\/jats:sec>\n \n Data synthesis<\/jats:title>\n \n Statistical analysis with\n SPSS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 575 studies were identified of which 27 met the inclusion criteria. These covered 727 patient episodes. For\n EPI<\/jats:styled-content>\n studies: sensitivity (\n sd<\/jats:sc>\n ) 71.82 (24.5), specificity (\n sd<\/jats:sc>\n ) 89.36 (13.4),\n PPV<\/jats:styled-content>\n (\n sd<\/jats:sc>\n ) 93.36 (8.1) and\n NPV<\/jats:styled-content>\n (\n sd<\/jats:sc>\n ) 73.36 (15.8). For non\u2010\n EPI<\/jats:styled-content>\n studies: sensitivity 89.79 (12.1), specificity (\n sd<\/jats:sc>\n ) 94.57 (5.8),\n PPV<\/jats:styled-content>\n (\n sd<\/jats:sc>\n ) 96.50 (4.2) and\n NPV<\/jats:styled-content>\n 80.46 (20.2). Improved sensitivity of non\u2010\n EPI<\/jats:styled-content>\n sequences reached significance (\n P<\/jats:italic>\n = 0.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Diffusion\u2010weighted\n MRI<\/jats:styled-content>\n is both sensitive and specific for the detection of recurrent or residual cholesteatoma following ear surgery. Non\u2010\n EPI<\/jats:styled-content>\n techniques are superior to\n EPI<\/jats:styled-content>\n techniques.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.12762","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T09:34:47Z","timestamp":1476264887000},"page":"536-543","source":"Crossref","is-referenced-by-count":82,"title":["Diffusion\u2010weighted magnetic resonance imaging for residual and recurrent cholesteatoma: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3065-0269","authenticated-orcid":false,"given":"J.","family":"Muzaffar","sequence":"first","affiliation":[{"name":"Queen Elizabeth Hospital Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Colley","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Coulson","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100119644"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055760"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489950180784"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.01.020"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1999.00238.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31822e938d"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.181.1.1810261"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.01.025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31815dbae8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1023-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200411000-00005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31378-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1100"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0160-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215112000679"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2010.11.004"},{"key":"e_1_2_8_19_1","first-page":"556","article-title":"Value of echo\u2010planar diffusion\u2010weighted MRI in the detection of secondary and postoperative relapsing\/residual cholesteatoma","volume":"107","author":"Stasolla A.","year":"2004","journal-title":"Radiol. 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