{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:45:01Z","timestamp":1772459101021,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Objective<\/jats:title>The aim of our study is to investigate whether systemic microvascular function affects the development and prognosis of sudden idiopathic hearing loss (SHL<\/jats:styled-content>).<\/jats:p><\/jats:sec>Type of study<\/jats:title>A prospective case\u2013control study.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>Fifty patients diagnosed with SHL<\/jats:styled-content> at our hospital between September 2015 and May 2016 were included as the SHL<\/jats:styled-content> group, and 50 healthy volunteers who came to the hospital for medical screening were included in the control group. Thirty\u2010one patients from the SHL<\/jats:styled-content> group who responded to treatment and 19 patients who did not respond to treatment were identified according to the Siegel criteria and were grouped. Patients with comorbid disorders were excluded from the study. To determine microvascular function, the videocapillaroscopic examination was conducted from the nailfold, measuring the capillary density (CD<\/jats:styled-content>) and post\u2010occlusive reactive hyperaemia (PORH<\/jats:styled-content>) values and statistical analysis was performed between the groups.<\/jats:p><\/jats:sec>Result<\/jats:title>While CD<\/jats:styled-content> was an average of 83.1 \u00b1 6 in the SHL<\/jats:styled-content> group, it was measured as 96.2 \u00b1 10 in the control group. The CD<\/jats:styled-content> value was significantly lower in the SHL<\/jats:styled-content> group than the control group (P<\/jats:italic> < 0.05). While the average PORH<\/jats:styled-content> value in the SHL<\/jats:styled-content> group was 80.5 \u00b1 7.7, it was measured as 97.5 \u00b1 10 in the control group. The PORH<\/jats:styled-content> value was significantly lower in the SHL<\/jats:styled-content> group than the control group (P<\/jats:italic> < 0.05). The CD<\/jats:styled-content> value did not differ significantly (P<\/jats:italic> > 0.05) between the group that responded to treatment (83.4 \u00b1 5.5) and the group that did not respond to treatment (82.7 \u00b1 6.9). The PORH<\/jats:styled-content> value was significantly lower (P<\/jats:italic> < 0.05) in the group that did not respond to treatment (75.2 \u00b1 7.9) than the group that did (83.8 \u00b1 5.6).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>To our best knowledge, our study is the first study in the literature. Although the role of specific mechanisms in SHL<\/jats:styled-content> is not entirely understood, the capillaroscopic examination can show the importance of microvascular function in SHL<\/jats:styled-content>. CD<\/jats:styled-content> and PORH<\/jats:styled-content> values were found to be low in SHL<\/jats:styled-content> patients, and a low PORH<\/jats:styled-content> value was found to be a factor of poor prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12780","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T02:22:36Z","timestamp":1476930156000},"page":"602-607","source":"Crossref","is-referenced-by-count":15,"title":["Microvascular dysfunction affects the development and prognosis of sudden idiopathic hearing loss"],"prefix":"10.1111","volume":"42","author":[{"given":"H.E.","family":"Ko\u00e7ak","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u015e.","family":"Filiz Ac\u0131payam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ac\u0131payam","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"\u00c7ak\u0131l Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.M.E.","family":"Alakhras","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.N.","family":"K\u0131ral","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.T.","family":"Kayhan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital Istanbul 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