{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:40:30Z","timestamp":1761896430082},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR\u2010104\u2010041"],"award-info":[{"award-number":["DMR\u2010104\u2010041"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Objectives<\/jats:title>This study correlated immunohistochemical studies with fluorodeoxyglucose (FDG<\/jats:styled-content>) uptake on positron emission tomography\u2013computed tomography (PET<\/jats:styled-content>\u2013CT<\/jats:styled-content>) and identified prognostic factors for radiotherapy (RT<\/jats:styled-content>)\u2010based treatment outcomes in patients with squamous cell carcinoma of the oropharynx and hypopharynx.<\/jats:p><\/jats:sec>Methods<\/jats:title>Genomic data from pre\u2010treatment biopsy specimens (Glut1<\/jats:italic>, CAIX<\/jats:styled-content><\/jats:italic>, VEGF<\/jats:styled-content><\/jats:italic>, HIF<\/jats:styled-content>\u20101\u03b1<\/jats:italic>, EGFR<\/jats:styled-content><\/jats:italic>, Ki\u201067<\/jats:italic>, Bcl\u20102<\/jats:italic>, CLAUDIN<\/jats:styled-content>\u20104<\/jats:italic>, YAP<\/jats:styled-content>\u20101<\/jats:italic>, c\u2010Met<\/jats:italic> and p16<\/jats:italic>) of 7<\/jats:italic>6 patients were analysed using tissue microarrays. FDG<\/jats:styled-content> uptake was evaluated using the maximum standardised uptake value (SUV<\/jats:styled-content>max), metabolic tumour volume (MTV<\/jats:styled-content>) and total lesion glycolysis (TLG<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>The overexpression of Glut1<\/jats:italic> positively associated with increased values of the SUV<\/jats:styled-content>max, MTV<\/jats:styled-content> and TLG<\/jats:styled-content>, whereas VEGF<\/jats:styled-content><\/jats:italic> and HIF<\/jats:styled-content>\u20101\u03b1<\/jats:italic> expression with the MTV<\/jats:styled-content> and TLG<\/jats:styled-content>, respectively. A VEGF<\/jats:styled-content><\/jats:italic> immunoreactive score (IRS<\/jats:styled-content>) >2 (P<\/jats:italic> = 0.001, hazard ratio [HR<\/jats:styled-content>] = 3.94) and an MTV<\/jats:styled-content> defined by an SUV<\/jats:styled-content> of 2.5 (MTV<\/jats:styled-content>2.5) >14.5 mL<\/jats:styled-content> (P<\/jats:italic> = 0.004, HR<\/jats:styled-content> = 3.31) were prognostic factors for low cause\u2010specific survival, whereas a VEGF<\/jats:styled-content><\/jats:italic> IRS<\/jats:styled-content> >2 (P<\/jats:italic> = 0.02, HR<\/jats:styled-content> = 2.83) for low primary relapse\u2010free survival.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The overexpression of Glut1<\/jats:italic>, VEGF<\/jats:styled-content><\/jats:italic> and HIF<\/jats:styled-content>\u20101\u03b1<\/jats:italic> associated with increased FDG<\/jats:styled-content> uptake. For patients with pharyngeal cancer requiring RT<\/jats:styled-content>, the treatment outcome can be stratified by VEGF<\/jats:styled-content><\/jats:italic> and MTV<\/jats:styled-content>2.5.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12783","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T08:32:52Z","timestamp":1476952372000},"page":"608-619","source":"Crossref","is-referenced-by-count":9,"title":["Immunohistochemical studies and fluorodeoxyglucose uptake on positron emission tomography in pharyngeal cancer for predicting radiotherapy\u2010based treatment outcomes"],"prefix":"10.1111","volume":"42","author":[{"given":"Y.\u2010C.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology China Medical University Hospital Taichung Taiwan"},{"name":"The Ph.D. Program for Cancer Biology and Drug Discovery China Medical University and Academia Sinica Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.\u2010Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology China Medical University Hospital Taichung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science School of Medicine College of Medicine China Medical University Taichung Taiwan"},{"name":"School of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.\u2010C.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Center China Medical University Hospital Taichung Taiwan"},{"name":"Department of Biomedical Imaging and Radiological Science China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010Y.","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Center China Medical University Hospital Taichung Taiwan"},{"name":"Department of Biomedical Imaging and Radiological Science China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010A.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology China Medical University Hospital Taichung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science School of Medicine College of Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010N.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology China Medical University Hospital Taichung Taiwan"},{"name":"Department of Biomedical Imaging and Radiological 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