{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:31:10Z","timestamp":1764570670159},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T00:00:00Z","timestamp":1481068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Honey reduced post\u2010tonsillectomy pain, but its effects on awakening at night, inflammation and healing of the tonsillar fossa were controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This systematic review and meta\u2010analysis of randomised controlled trials (RCTs) evaluated the effect of oral honey on pain, consumption of painkillers, awakening at night, healing of tonsillar fossa and adverse effects in children after tonsillectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search of MEDLINE, EMBASE, Scopus, CINAHL and Cochrane Collaboration Library databases was performed without any restriction of publication year. The end date of search was 30 June 2016. The search was supplemented by search from Google, hand search of cross\u2010references of selected articles and reviews, and contacting the authors of different studies. The inclusion criteria were RCTs comparing the effect of honey with control on different outcomes, in children after tonsillectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our search generated 64 studies, and eight RCTs met our inclusion criteria. The methodological quality of RCTs was poor. Compared to control, honey significantly decreased postoperative pain from day 1 to day 7 (<jats:italic>P<\/jats:italic> = 0.05 to &lt;0.0001); consumption of painkillers from days 1 to 5 (<jats:italic>P<\/jats:italic> = 0.03 to 0.003) and on day 10 (<jats:italic>P<\/jats:italic> = 0.002); and number of awakening at night due to pain on days 2 and 4 after tonsillectomy (<jats:italic>P<\/jats:italic> = 0.0001, 0.004). The healing of tonsillar fossa was significantly greater with honey compared to control on days 3\u20134 (<jats:italic>P<\/jats:italic> = 0.02) and days \u22659 (<jats:italic>P<\/jats:italic> = 0.01) after tonsillectomy. The adverse effects were not significantly different between honey and control groups. The Grading of Recommendation, Assessment, Development and Evaluation (GRADE) of the evidence for different outcomes varied from \u2018low\u2019 to \u2018very low\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Honey improved pain, requirement of painkillers and awakening at night due to pain in children after tonsillectomy. There was little improvement in healing of tonsillar fossa. The GRADE of the evidence varied from \u2018low\u2019 to \u2018very low\u2019. A good\u2010quality, placebo\u2010controlled RCT of different doses and durations of administration of honey is required to evaluate its clear efficacy and safety in children after tonsillectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12792","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T03:37:42Z","timestamp":1479181062000},"page":"651-660","source":"Crossref","is-referenced-by-count":31,"title":["Role of honey after tonsillectomy: a systematic review and meta\u2010analysis of randomised controlled trials"],"prefix":"10.1111","volume":"42","author":[{"given":"A.","family":"Lal","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine University Hospital London ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Chohan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chohan","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chakravarti","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010 Head and Neck Surgery Lady Hardinge Medical College New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70376-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2014.07.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.11.036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1207-72"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2013.05.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3433-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5606\/kbbihtisas.2015.00008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(96)01456-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.05.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200110000-00008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70040-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.03.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199904000-00025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.07.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.08.018"},{"key":"e_1_2_9_17_1","article-title":"Honey versus diphenhydramine for post\u2010tonsillectomy pain relief in pediatric cases: a randomized clinical trial","volume":"9","author":"Amani S.","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.9246"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2015\/115"},{"key":"e_1_2_9_20_1","first-page":"e21045","article-title":"Can honey be used as an adjunct in treatment of post tonsillectomy pain?","volume":"14","author":"Hasanzadeh Kiabi F.","year":"2014","journal-title":"Anesth. Pain Med."},{"key":"e_1_2_9_21_1","unstructured":"NiaF.H. MohebbiS.M.&AbdR.(2014).Effect of oral honey intake on post\u2010tonsillectomy pain in children. 2014; 85th Annual Meeting German Society of Oto\u2010Rhino\u2010Laryngology Head and Neck Surgery Dortmund"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(94)90150-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90004-3"},{"key":"e_1_2_9_24_1","first-page":"185","volume-title":"Honey: Current Research and Clinical Uses","author":"Kamaruddin M.Y.","year":"2012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-150789"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0926-6569(63)90108-1"},{"key":"e_1_2_9_27_1","first-page":"229","article-title":"Isolation and identification of phenolic acids in Malaysian honey with anti\u2010bacterial properties","volume":"33","author":"Aljadi A.M.","year":"2003","journal-title":"Turk. J. Med. Sci."},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.07.024"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.78"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/109662003322233530"},{"key":"e_1_2_9_31_1","first-page":"83","article-title":"Antimicrobial effect of bee honey in comparison to antibiotics on organisms isolated from infected burns","volume":"30","author":"Abd\u2010El Aal A.M.","year":"2007","journal-title":"Ann. Burns Fire Disasters"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005607"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215054516223"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6815-11-9"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12792","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:42:15Z","timestamp":1696358535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,7]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/coa.12792"],"URL":"https:\/\/doi.org\/10.1111\/coa.12792","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,7]]}}}