{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T19:53:05Z","timestamp":1719172385496},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In patients with a history of lymphoma, each lymphadenopathy should be carefully evaluated. The aims of this study were to evaluate (i) the usefulness of high\u2010resolution ultrasonography (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\u2010guided fine\u2010needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>) and flow cytometry phenotyping (<jats:styled-content style=\"fixed-case\">FCP<\/jats:styled-content>) together in the diagnosis of recurrent lymphoma and (ii) whether these tools were independent predictors of correct results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study with stepwise forward logistic regression analysis of results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 151 patients with a history of lymphoma who developed a cervical mass during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>On neck <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>, a lymphadenopathy was shown in 129 (85.4%) patients (median age 57 years, range 18\u201378 years), and <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\u2010guided <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> combined with <jats:styled-content style=\"fixed-case\">FCP<\/jats:styled-content> were immediately performed. All patients had surgical excision and subsequent histological examination of the enlarged node(s), to establish lymphoma subclassification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Final histology confirmed recurrence in 82 (63.6%) patients. According to the logistic regression analysis, <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FCP<\/jats:styled-content> were independent predictors of correct results (<jats:italic>P<\/jats:italic> = 0.009 and 0.028, respectively) and did not interfere with each other. The sensitivity, specificity and accuracy of the combination of all of the tools were 98.8%, 100% and 99.2%, respectively, and the area under the receiver operating characteristic curve was 0.902 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.797\u20130.986).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This minimally invasive procedure is easily performed and should be recommended for all patients with cervical lymphadenopathy and a history of lymphoma, avoiding the need of core\u2010biopsy or surgical excision if recurrence was excluded.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12797","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T07:26:49Z","timestamp":1479972409000},"page":"668-672","source":"Crossref","is-referenced-by-count":2,"title":["Image\u2010guided fine\u2010needle aspiration cytology and flow cytometry phenotyping of neck lymphadenopathy for the diagnosis of recurrent lymphoma"],"prefix":"10.1111","volume":"42","author":[{"given":"F.","family":"Lumachi","sequence":"first","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology School of Medicine University of Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fassina","sequence":"additional","affiliation":[{"name":"2nd Pathology and Cytopathology Unit Department of Medicine School of Medicine University of Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tozzoli","sequence":"additional","affiliation":[{"name":"Clinical Pathology Laboratory Department of Laboratory Medicine S. Maria degli Angeli Hospital Pordenone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tregnaghi","sequence":"additional","affiliation":[{"name":"Radiology Service Madonna della Navicella Hospital Chioggia VE Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.M.","family":"Basso","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Surgery S. Maria degli Angeli Hospital Pordenone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ermani","sequence":"additional","affiliation":[{"name":"Statistic and Informatics Unit Department of Neurosciences School of Medicine University of Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_9_3_1","unstructured":"National Cancer Institute.Surveillance Epidemiology and End Results Program (SEER). Hodgkin's and non\u2010Hodgkin's lymphoma. Available at:http:\/\/seer.cancer.gov\/statfacts\/html\/nhl.htmlandhttp:\/\/seer.cancer.gov\/statfacts\/html\/hodg.html[accessed on March 15 2016]"},{"key":"e_1_2_9_4_1","unstructured":"AIOM\u2010CCM\u2010AIRTUM.I numeri del cancro in Italia 2015.http:\/\/www.registri-tumori.it\/PDF\/AIOM2015\/I_numeri_del_cancro_2015.pdf[accessed on 15 June 2016]"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7534"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.5860"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2013.0056"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15381"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ruq.0000263839.84937.45"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21448"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9047"},{"key":"e_1_2_9_12_1","first-page":"5255","article-title":"FNA cytology and frozen section examination in patients with follicular lesions of the thyroid gland","volume":"29","author":"Lumachi F.","year":"2009","journal-title":"Anticancer Res."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.129"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22730"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880336"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds273"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu200"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0674-RA"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2014.09.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21821"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2015.04.015"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-012-0149-1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2014.993088"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03804.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21561"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181827da8"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:41:48Z","timestamp":1696358508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,18]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/coa.12797"],"URL":"https:\/\/doi.org\/10.1111\/coa.12797","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,18]]}}}