{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:08:31Z","timestamp":1790287711946,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,8]],"date-time":"2017-01-08T00:00:00Z","timestamp":1483833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["10049035"],"award-info":[{"award-number":["10049035"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between the parameters of 24\u2010hour multichannel intraluminal impedance (<jats:styled-content style=\"fixed-case\">MII<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring and the symptoms or quality of life (QoL) in laryngopharyngeal reflux (<jats:styled-content style=\"fixed-case\">LPR<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study without controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five <jats:styled-content style=\"fixed-case\">LPR<\/jats:styled-content> patients were selected from subjects who underwent 24\u2010hour <jats:styled-content style=\"fixed-case\">MII<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring and were diagnosed with <jats:styled-content style=\"fixed-case\">LPR<\/jats:styled-content> from September 2014 to May 2015. Reflux Symptom Index (<jats:styled-content style=\"fixed-case\">RSI<\/jats:styled-content>), Health\u2010related Quality of Life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL), Short Form 12 (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201012) Survey questionnaires were surveyed. Spearman's correlation was used to analyse the association between the symptoms or QoL and 24\u2010hour <jats:styled-content style=\"fixed-case\">MII<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most parameters in 24\u2010hour <jats:styled-content style=\"fixed-case\">MII<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring showed weak or no correlation with <jats:styled-content style=\"fixed-case\">RSI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HRQ<\/jats:styled-content>oL and <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201012. Only number of non\u2010acid reflux events that reached the larynx and pharynx (<jats:styled-content style=\"fixed-case\">LPR<\/jats:styled-content>\u2010non\u2010acid) and number of total reflux events that reached the larynx and pharynx (<jats:styled-content style=\"fixed-case\">LPR<\/jats:styled-content>\u2010total) parameters showed strong correlation with heartburn in <jats:styled-content style=\"fixed-case\">RSI<\/jats:styled-content> (<jats:italic>R<\/jats:italic> = 0.520, <jats:italic>P<\/jats:italic> &lt; 0.001, <jats:italic>R<\/jats:italic> = 0.478, <jats:italic>P<\/jats:italic> = 0.001, respectively). Multiple regression analysis showed that there was only one significant regression coefficient between <jats:styled-content style=\"fixed-case\">LPR<\/jats:styled-content>\u2010non\u2010acid and voice\/hoarseness portion of <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL (<jats:italic>b<\/jats:italic> = 1.719, <jats:italic>P<\/jats:italic> = 0.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most parameters of 24\u2010hour <jats:styled-content style=\"fixed-case\">MII<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring did not reflect subjective symptoms or QoL in patients with <jats:styled-content style=\"fixed-case\">LPR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12817","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T09:24:20Z","timestamp":1482398660000},"page":"584-591","source":"Crossref","is-referenced-by-count":24,"title":["Association between 24\u2010hour combined multichannel intraluminal impedance\u2010<scp>pH<\/scp> monitoring and symptoms or quality of life in patients with laryngopharyngeal reflux"],"prefix":"10.1111","volume":"42","author":[{"given":"S.I.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.E.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Y.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.G.","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.2.108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200404000-00014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.12.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200303000-00003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24737"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30349.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.2.157"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5493"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i19.2401"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00854-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200209000-00014"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.4.315"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12287"},{"key":"e_1_2_9_16_1","first-page":"184","article-title":"Laryngopharyngeal reflux: diagnosis, treatment, and latest research","volume":"18","author":"Campagnolo A.M.","year":"2014","journal-title":"Int. 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