{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:10:57Z","timestamp":1769155857412,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004734","name":"Jewish General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004361","name":"Krebsliga Schweiz","doi-asserted-by":"publisher","award":["KFS\u20103002\u201008\u20102012"],"award-info":[{"award-number":["KFS\u20103002\u201008\u20102012"]}],"id":[{"id":"10.13039\/501100004361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The extent of initial surgical management in papillary thyroid cancer (<jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>) is controversial. We examined whether the presence of perioperative antithyroglobulin antibodies (<jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>) could predict long\u2010term recurrence and occurrence of adverse features among a homogenous group of patients with <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical features of patients with <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> treated at a single institution (Jewish General Hospital, McGill University, Montreal, Canada) were obtained from the medical records, and all clinicopathologic information was reviewed. Only low\u2010risk <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> without clinical evidence of nodal disease before surgery and treated with 30 mCi of radioactive iodine was included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The chart review retrieved 361 patients with a median follow\u2010up of 85.0 months (Q25\u2010Q75 73\u201098). Forty\u2010two (11.6%) patients had presence of perioperative <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>. Perioperative <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>s were associated with present extrathyroidal extension (<jats:italic>P<\/jats:italic>=.005), unsuspected nodal disease (<jats:italic>P<\/jats:italic>=.001) and autoimmune thyroiditis (<jats:italic>P<\/jats:italic>&lt;.0001). Overall, 17 (4.7%) patients experienced locoregional recurrence. Perioperative <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>s were a significant predictor of recurrence in univariable (<jats:italic>P<\/jats:italic>=.021) but not in multivariable analysis (<jats:italic>P<\/jats:italic>=.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Presence of perioperative <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>s is associated with aggressive histological features and the presence of thyroiditis. Detection of <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content> perioperatively may encourage surgeons to consider more extensive initial surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12835","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T13:27:19Z","timestamp":1485523639000},"page":"1130-1134","source":"Crossref","is-referenced-by-count":9,"title":["Clinicopathological relevance of antithyroglobulin antibodies in low\u2010risk papillary thyroid cancer"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-6772","authenticated-orcid":false,"given":"G.B.","family":"Morand","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Sir Mortimer B. Davis\u2010Jewish General Hospital McGill University Montreal QC Canada"},{"name":"Departments of Medicine and Oncology Segal Cancer Centre and Lady Davis Institute for Medical Research Sir Mortimer B. 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