{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:43:53Z","timestamp":1792885433832,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,26]],"date-time":"2017-02-26T00:00:00Z","timestamp":1488067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2016M3A9E8942068"],"award-info":[{"award-number":["2016M3A9E8942068"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Current preoperative diagnosis of thyroid nodules remains imperfect despite recent advances in cytopathology and molecular diagnostics. False positivity in preoperative fine\u2010needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>) may lead to overtreatment of patients, including total thyroidectomy, and sometimes to lawsuits for misdiagnosis and malpractice. In this study, we analysed clinical characteristics and pathologic findings in patients with false positivity for papillary thyroid carcinoma (<jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed permanent pathology results from 3788 patients who underwent thyroid surgery. Among them, 48 patients had lesions that were deemed suspicious or positive (Bethesda class V or <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> in preoperative <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>. We reviewed clinic\u2013pathologic data, radiologic findings and surgical planning in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of pathologic thyroiditis was significantly higher among patients with false\u2010positive <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> results than in those with confirmed <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> (54.2% vs 9.2%, <jats:italic>P<\/jats:italic>&lt;.001). The analysis of the permanent pathology reports showed that 26 patients had chronic lymphocytic thyroiditis and 22 patients had no evidence of thyroiditis. Among the patients without pathologic thyroiditis, 19 patients (86.4%) had nodular hyperplasia and three (13.6%) had follicular adenoma, while among the patients with pathologic thyroiditis, seven (26.9%) had no nodule, 14 (53.8%) had nodular hyperplasia, two (7.7%) had hyalinized nodules, two (7.7%) had follicular adenoma and one (3.8%) had a hyalinizing trabecular tumour. In 42 patients, the extent of surgery (total thyroidectomy or hemithyroidectomy) was to be determined according to the intra\u2010operative frozen section biopsy results. Among them, four (10.5%) had inconclusive frozen section results, and 38 (90.5%) had benign results on frozen section.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patient counselling about the possibility of false positivity is still important. And the presence of thyroiditis might create confusion in the interpretation of cytopathologic results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12840","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T15:27:00Z","timestamp":1485617220000},"page":"1153-1160","source":"Crossref","is-referenced-by-count":24,"title":["False\u2010positive cytopathology results for papillary thyroid carcinoma: A trap for thyroid surgeons"],"prefix":"10.1111","volume":"42","author":[{"given":"K.\u2010I.","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery and Biomedical Research Institute Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Pathology Pusan National University Hospital Busan 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