{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:33:29Z","timestamp":1792020809474,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,26]],"date-time":"2017-02-26T00:00:00Z","timestamp":1488067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/1242"],"award-info":[{"award-number":["PI13\/1242"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["PI13\/1242"],"award-info":[{"award-number":["PI13\/1242"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To define clinical subgroups by cluster analysis in patients with unilateral Meniere disease (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) and to compare them with the clinical subgroups found in bilateral <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study with a two\u2010step cluster analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>A tertiary referral multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Nine hundred and eighty\u2010eight adult patients with unilateral <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>. Main outcome measures: best predictors to define clinical subgroups with potential different aetiologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We established five clusters in unilateral <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>. Group 1 is the most frequently found, includes 53% of patients, and it is defined as the sporadic, classic <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> without migraine and without autoimmune disorder (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>). Group 2 is found in 8% of patients, and it is defined by hearing loss, which antedates the vertigo episodes by months or years (delayed <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>), without migraine or <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in most of cases. Group 3 involves 13% of patients, and it is considered familial <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>, while group 4, which includes 15% of patients, is linked to the presence of migraine in all cases. Group 5 is found in 11% of patients and is defined by a comorbid <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. We found significant differences in the distribution of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in clusters 3, 4 and 5 between patients with uni\u2010 and bilateral <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cluster analysis defines clinical subgroups in <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>, and it extends the phenotype beyond audiovestibular symptoms. This classification will help to improve the phenotyping in <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> and facilitate the selection of patients for randomised clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12844","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T19:53:15Z","timestamp":1486410795000},"page":"1172-1180","source":"Crossref","is-referenced-by-count":154,"title":["Extended phenotype and clinical subgroups in unilateral Meniere disease: A cross\u2010sectional study with cluster analysis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-0941","authenticated-orcid":false,"given":"L.","family":"Frejo","sequence":"first","affiliation":[{"name":"Otology &amp; Neurotology Group CTS495 Department of Genomic Medicine\u2010 Centro de Gen\u00f3mica e Investigaci\u00f3n Oncol\u00f3gica \u2013 Pfizer\/Universidad de Granada\/Junta de Andaluc\u00eda (GENYO) Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-3844","authenticated-orcid":false,"given":"E.","family":"Martin\u2010Sanz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital Universitario de Getafe Getafe Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Teggi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology San Raffaelle Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Trinidad","sequence":"additional","affiliation":[{"name":"Division of Otoneurology Department of Otorhinolaryngology Complejo Hospitalario Universitario de Badajoz Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Soto\u2010Varela","sequence":"additional","affiliation":[{"name":"Division of Otoneurology Department of Otorhinolaryngology Complexo Hospitalario Universitario Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Santos\u2010Perez","sequence":"additional","affiliation":[{"name":"Division of Otoneurology Department of Otorhinolaryngology Complexo Hospitalario Universitario Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Manrique","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Clinica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Clinica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Aran","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Complexo Hospitalario de Pontevedra Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Almeida\u2010Branco","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital de Poniente El Ejido Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Batuecas\u2010Caletrio","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital Universitario Salamanca Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fraile","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital Miguel Servet Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Espinosa\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Otology &amp; 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