{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:20:57Z","timestamp":1792167657190,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,19]],"date-time":"2017-03-19T00:00:00Z","timestamp":1489881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluation of the influence of a smooth surface moulding technique of silicone rubber indwelling voice prostheses on <jats:italic>in vitro<\/jats:italic> biofilm formation and analysis of the clinical in situ lifetime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Biofilm formation on smooth and Groningen ultra low resistance (<jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>) prostheses was studied in an artificial throat model. The clinical lifetime of smooth voice prostheses was compared to the previous lifetime of <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content> by counting the number of replacements in a consecutive 6\u2010month period in the same patient. Participants: Eleven laryngectomised patients in follow\u2010up who required frequent replacement of their voice prostheses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>Tertiary University Medical Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Use of a smoother mould and less viscous silicone rubber yielded a decrease in surface roughness from 46 to 8 nm and was accompanied by a 40% reduction in the prevalence of bacteria and yeast in <jats:italic>in vitro<\/jats:italic> formed biofilms. Clinically, the lifetime was significantly (<jats:italic>P<\/jats:italic>&lt;.005) increased by a factor of 2.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This combined <jats:italic>in vitro<\/jats:italic> and clinical study suggests that the choice of material and in particular its surface finishing may be determining factors with respect to the clinical lifetime of silicone rubber implants and devices failing due to biofilm formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12856","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T05:06:38Z","timestamp":1487999198000},"page":"1235-1240","source":"Crossref","is-referenced-by-count":11,"title":["Influence of surface roughness on silicone rubber voice prostheses on <i>in vitro<\/i> biofilm formation and clinical lifetime in laryngectomised patients"],"prefix":"10.1111","volume":"42","author":[{"given":"K.J.D.A.","family":"Buijssen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University of Groningen, University Medical Center Groningen Groningen The Netherlands"},{"name":"Department of Biomedical Engineering University of Groningen, University Medical Center Groningen Groningen The Netherlands"},{"name":"Department of Otorhinolaryngology Albert Schweitzer Hospital Dordrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.H.","family":"Oosterhof","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Basil","sequence":"additional","affiliation":[{"name":"Principality Medical Ltd. Newport UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Waters","sequence":"additional","affiliation":[{"name":"Principality Medical Ltd. Newport UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Duits","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J.","family":"Busscher","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.C.","family":"van der Mei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-2871","authenticated-orcid":false,"given":"B.F.A.M.","family":"van der Laan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"73","volume-title":"Biomaterials in Reconstructive Surgery","author":"Frisch EE","year":"1983"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pi.1273"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137724"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1993.tb00627.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21833"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104508"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100302"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjn090"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(97)70148-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01353.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00542-2"},{"key":"e_1_2_7_13_1","volume-title":"NuSil Technology LCC","author":"Product Profile MED\u20104735, MED\u20104750 & MED\u20104765","year":"2004"},{"key":"e_1_2_7_14_1","volume-title":"NuSil Technology LCC","author":"Product Profile MED\u20104850","year":"2006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022952712257"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2011.03.017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/08927010109378465"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2006.05.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221503322542881"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20180"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20925"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:28:32Z","timestamp":1695551312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,19]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/coa.12856"],"URL":"https:\/\/doi.org\/10.1111\/coa.12856","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,19]]}}}