{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:03:47Z","timestamp":1788829427044,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluate the clinical outcome of patients treated with CO<jats:sub>2<\/jats:sub> laser surgery for early\u2010stage glottic carcinomas followed up with 3\u2010month laryngoscopy regardless of tumor grade and margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Retrospective review of the clinical records of patients treated at the ENT department of a tertiary university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants and method<\/jats:title><jats:p>Clinical records from patients with early\u2010stage glottic carcinomas (Tis\/T2) treated with curative intent by CO<jats:sub>2<\/jats:sub> laser surgery in a ten\u2010year period were evaluated. Regardless of tumor margin status, patients underwent fiber endoscopy 6 weeks after surgery and a systematic second look by direct laryngoscopy under general anesthesia at 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Local control, laryngeal preservation rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010three patients were included. Disease control was obtained in 90\/93 cases. Laryngeal preservation rate was 96.8%. Twenty patients had a local residual disease or recurrence after the first laser surgery, but 17 were salvaged (85%). Local residual disease and recurrence were more frequent in patients with advanced disease (T1b\/T2), invasion of anterior commissure and \u201cnon\u2010safe\u201d margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed follow\u2010up scheme might be a valuable option, but with caution for positive or unevaluable margins as the latter is an independent risk factor for local recurrence. An early laser excision procedure (eg, within the first two months after surgery) or an alternative strategy may be discussed in this situation. \u201cWatchful observation\u201d should be reserved for compliant patients only so that the risk of missing potential recurrences is minimised.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12863","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T16:10:42Z","timestamp":1489162242000},"page":"1193-1199","source":"Crossref","is-referenced-by-count":20,"title":["\u201cWatchful observation\u201d follow\u2010up scheme after endoscopic <scp>CO<\/scp><sub>2<\/sub> laser treatment for small glottic carcinomas: A retrospective study of 93 cases"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-1707","authenticated-orcid":false,"given":"P.","family":"Gallet","sequence":"first","affiliation":[{"name":"Department of ENT and head and neck surgery University Hospital Nancy 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