{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:40:41Z","timestamp":1782283241551,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the prevalence of obstructive sleep apnoea syndrome (OSAS) in a population of patients treated for an advanced oropharyngeal cancer (AJCC Stage III or IV), depending on treatment strategy, and to evaluate its impact on quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University Teaching Hospital of La Conception, Marseille, France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Fifty\u2010one disease\u2010free patients were included. Forty\u2010one patients received a combined chemoradiotherapy, while 10 patients were treated by surgery followed by chemoradiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Every patient underwent a formal sleep consultation and was asked to complete the Epworth Sleepiness Scale and EORTC QLQ C\u201030 and the EORTC H&amp;N 35 questionnaires. A home overnight respiratory polygraphy was performed in every subject.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean time between the end of cancer treatment and the OSAS analysis was 54.04 months [20; 84]. An OSAS was found in 25.49% of our patients. There was no significant difference between patients treated with either surgery (30%) or CRT (24.39%), <jats:italic>P<\/jats:italic>=.79. The EORTC QLQ C\u201030 questionnaire showed a significant difference between positive and negative OSAS groups in the Global Health Status Scale (50.64 vs 67.11, <jats:italic>P<\/jats:italic>=.02) and in the fatigue item (35.04 vs 17.25, <jats:italic>P<\/jats:italic>=.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our population with advanced oropharyngeal cancer, whatever the treatment strategy it may be, was at risk of developing OSAS with negative impact on quality of life. A routine screening and treatment of OSAS seems necessary to improve the quality of life of patients treated for advanced oropharyngeal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12869","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T06:44:45Z","timestamp":1490337885000},"page":"1281-1288","source":"Crossref","is-referenced-by-count":25,"title":["Prevalence of obstructive sleep apnoea syndrome following oropharyngeal cancer treatment: A prospective cohort study"],"prefix":"10.1111","volume":"42","author":[{"given":"A.","family":"Loth","sequence":"first","affiliation":[{"name":"Service d'ORL et Chirurgie Cervico\u2010Faciale Centre Hospitalier Universitaire La Conception APHM Aix Marseille Univ Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Michel","sequence":"additional","affiliation":[{"name":"Service d'ORL et Chirurgie Cervico\u2010Faciale Centre Hospitalier Universitaire La Conception 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