{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:00:31Z","timestamp":1740171631430,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the rationale for investigating patients presenting with globus symptoms. In this regard, we also assess the efficacy and safety of transnasal flexible laryngo\u2010oesophagoscopy (<jats:styled-content style=\"fixed-case\">TNFLO<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study in a head and neck cancer centre of patients with persistent globus symptoms with normal flexible nasoendoscopy\/indirect mirror laryngoscopy and failure of first\u2010line medical treatment. The role of <jats:styled-content style=\"fixed-case\">TNFLO<\/jats:styled-content> in investigating these patients was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 218 patients were recruited in this study. Positive findings included upper aerodigestive cancers in two patients, other pathologies included reflux (four patients), cricopharyngeus\u2010related pathologies (19 patients), candida (five patients). There were only five re\u2010referrals of patients who were discharged following normal examination with <jats:styled-content style=\"fixed-case\">TNFLO<\/jats:styled-content>. In nine patients, <jats:styled-content style=\"fixed-case\">TNFLO<\/jats:styled-content> could not be completed and they went on to have other diagnostic procedures<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This article is the largest to date in the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> to assess the role of <jats:styled-content style=\"fixed-case\">TNFLO<\/jats:styled-content> in investigating patients with globus symptoms. <jats:styled-content style=\"fixed-case\">TNFLO<\/jats:styled-content> is equal to rigid endoscopy as a diagnostic tool. 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