{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T07:03:17Z","timestamp":1774767797276,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,9]],"date-time":"2017-04-09T00:00:00Z","timestamp":1491696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hearing loss and otitis media are frequently reported in patients with 22q11.2 deletion syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective of review<\/jats:title><jats:p>Our objective was to review the current literature on the prevalence of hearing loss and otologic manifestations in patients with 22q11.2 deletion syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Type of review<\/jats:title><jats:p>Systematic review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>We conducted a systematic search in PubMed and Embase combining the term \u201c22q11.2 deletion syndrome\u201d and synonyms with \u201chearing loss\u201d and \u201cotologic manifestations\u201d and synonyms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evaluation method<\/jats:title><jats:p>We screened title\/abstract and full text of all retrieved articles on pre\u2010defined in\u2010 and exclusion criteria. The remaining articles were assessed on risk of bias. Outcome measures included the prevalence of hearing loss and otologic manifestations such as otitis media.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our search yielded 558 unique studies of which a total of 25 articles were included for critical appraisal and data extraction. Twenty\u2010one studies reported on hearing loss, and 21 studies on otologic manifestations. The prevalence of hearing loss varied from 6.0% to 60.3%, where in most studies conductive hearing loss was most prevalent. Rates of recurrent or chronic otitis media varied from 2.2% to 89.8%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although a very broad range in prevalences is reported in different studies, hearing loss and recurrent or chronic otitis media are frequently present in patients with 22q11.2 deletion syndrome. Regular check\u2010ups and audiometric testing are advised in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12874","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T09:54:22Z","timestamp":1490090062000},"page":"1319-1328","source":"Crossref","is-referenced-by-count":26,"title":["Prevalence of hearing loss and clinical otologic manifestations in patients with 22q11.2 deletion syndrome: A literature review"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-2582","authenticated-orcid":false,"given":"E.","family":"Verheij","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The 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