{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:14:06Z","timestamp":1791656046208,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to find a correlation between closure technique in pharyngeal closure and outcomes of both pharyngocutaneous fistula and post\u2010laryngectomy stricture after laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective Chart\u00a0Review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed a total of 151 patients over a 20\u2010year period from January 1994 to December of 2013 who underwent primary pharyngeal reconstruction after total laryngectomy specifically looking at the closure technique in relation to pharyngo\u2010cutaneous fistula (<jats:styled-content style=\"fixed-case\">PCF<\/jats:styled-content>) and post\u2010laryngectomy stricture postoperatively. Patients were excluded based on secondary pharyngeal closure. Using logistic regression modelling, we performed univariate and multivariate analyses of our data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall <jats:styled-content style=\"fixed-case\">PCF<\/jats:styled-content> and post\u2010laryngectomy stricture rates were 19.1% and 15.8%. When salvage laryngectomy was excluded, t\u2010type closure had a significantly lower risk of fistula rate (<jats:italic>P<\/jats:italic>=.038) compared to vertical closure. In multivariate analysis, this statistical significance was lost (<jats:italic>P<\/jats:italic>=.23); however, non\u2010salvage t\u2010type closure remained significantly better than both salvage laryngectomy groups (t\u2010type, <jats:italic>P<\/jats:italic>=.033, vertical, <jats:italic>P<\/jats:italic>=.037), while non\u2010salvage vertical closure had no significant difference from other groups. There was no difference in stricture rate between the two closure techniques (<jats:italic>P<\/jats:italic>=.63).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study supports the role of t\u2010type closure decreasing fistula rates in primary pharyngeal reconstruction. Orientation of the pharyngeal closure does not appear to change the risk of post\u2010laryngectomy stricture formation after total laryngectomy. Salvage laryngectomy with primary pharyngeal reconstruction remains an independent risk factor for fistula formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12905","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T15:41:35Z","timestamp":1495554095000},"page":"109-116","source":"Crossref","is-referenced-by-count":36,"title":["Post\u2010Laryngectomy stricture and pharyngocutaneous fistula: Review of techniques in primary pharyngeal reconstruction in laryngectomy"],"prefix":"10.1111","volume":"43","author":[{"given":"B.","family":"Walton","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Texas Medical Branch Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Vellucci","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Texas Medical Branch Galveston TX 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