{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:39:53Z","timestamp":1788514793896,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean government, MSIP","award":["NRF-2015M3A9E2029189"],"award-info":[{"award-number":["NRF-2015M3A9E2029189"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse the association between 24\u2010hour multichannel intraluminal impedance\u2010pH (24\u2010h MII\u2010pH) parameters and each item of the reflux finding score (RFS) to determine whether the laryngoscopic findings of the RFS could reflect the characteristics of reflux in patients with laryngopharyngeal reflux (LPR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>Tertiary care referral medical centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients complaining of LPR symptoms were evaluated via a 24\u2010hour MII\u2010pH. Among them, 99 patients whose LPR was confirmed via 24\u2010hour MII\u2010pH were enrolled in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Correlations between RFS ratings and 24\u2010hour MII\u2010pH parameters were evaluated and compared between patients with or without each laryngoscopic finding used in the RFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subglottic oedema had a statistically significant positive correlation with number of non\u2010acid LPR and non\u2010acid full column reflux events. Ventricular obliteration and posterior commissure hypertrophy showed a significant correlation with non\u2010acid exposure time and total reflux exposure time. We also found a significant correlation between granuloma\/granulation score and number of acid LPR events. The numbers of non\u2010acid LPR and full column reflux events in patients with subglottic oedema were significantly higher than those without subglottic oedema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among the laryngoscopic findings used in the RFS, subglottic oedema is specific for non\u2010acid reflux episodes, and granuloma\/granulation is specific for acid reflux episodes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12914","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T11:32:46Z","timestamp":1497267166000},"page":"137-143","source":"Crossref","is-referenced-by-count":23,"title":["Do laryngoscopic findings reflect the characteristics of reflux in patients with laryngopharyngeal reflux?"],"prefix":"10.1111","volume":"43","author":[{"given":"Y.C.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.E.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-5207","authenticated-orcid":false,"given":"Y.G.","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.12.1534"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1741-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200108000-00001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948509400521"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23693"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00778.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100509"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.05.033"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311201006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2005.09.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.01.006"},{"issue":"1","key":"e_1_2_7_14_1","first-page":"1","article-title":"Review article: reflux and its consequences\u2013the laryngeal, pulmonary and oesophageal manifestations. 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