{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:26:00Z","timestamp":1773296760771,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the influence of cerebral venous drainage on the pathogenesis of idiopathic sudden sensorineural hearing loss (<jats:styled-content style=\"fixed-case\">ISSHL<\/jats:styled-content>) and M\u00e9ni\u00e8re syndrome (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational, prospective, cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ENT<\/jats:styled-content> and Cardiology Departments (University of Bari, Policlinico Hospital, Bari, Italy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>We enrolled 59 consecutive patients (32 males, mean age 53.05 <jats:styled-content>+<\/jats:styled-content> 15.37 years): 40 <jats:styled-content style=\"fixed-case\">ISSHL<\/jats:styled-content> and 19 <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>All patients underwent physical examination, biochemical evaluation (glycemic and lipid profile, viral serology, C reactive protein, etc), audiometric (tonal, vocal, vestibular evoked myogenic potentials and auditory brainstem response test) and impedentiometric examination. The pure tone average (<jats:styled-content style=\"fixed-case\">PTA<\/jats:styled-content>) was calculated for the following frequencies: 250, 500, 1000, 2000, 3000, 4000, 8000. An echo\u2010color Doppler evaluation of the venous cerebral veins, internal jugular (<jats:styled-content style=\"fixed-case\">IJV<\/jats:styled-content>) and vertebral veins (<jats:styled-content style=\"fixed-case\">VV<\/jats:styled-content>) at supine and 90\u00b0 position was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No morphological alterations were found both in patients and controls. There were no signs of stenosis, blocked flow, membranes, etc. We found lower minimum, mean and maximum velocities in distal <jats:styled-content style=\"fixed-case\">IJV<\/jats:styled-content>s (<jats:italic>P<\/jats:italic> = .019; <jats:italic>P<\/jats:italic> = .013; <jats:italic>P<\/jats:italic> = .022; respectively) and left <jats:styled-content style=\"fixed-case\">VV<\/jats:styled-content>s (<jats:italic>P<\/jats:italic> = .027; <jats:italic>P<\/jats:italic> = .008; <jats:italic>P<\/jats:italic> = .001; respectively) in supine (0\u00b0) position in both <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ISSHL<\/jats:styled-content> patients as compared to controls. The same was for orthostatic position (90\u00b0). We found negative correlations between the velocities in extracranial veins and <jats:styled-content style=\"fixed-case\">PTA<\/jats:styled-content> values: therefore, the worst the audiometric performance of the subjects, the lower the velocities in the venous cerebral drainage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Idiopathic sudden sensorineural hearing loss and M\u00e9ni\u00e8re syndrome patients showed altered venous flow in <jats:styled-content style=\"fixed-case\">IJV<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">VV<\/jats:styled-content>s as compared to controls, independently from posture. This different behavior of venous tone control can influence the ear performance and may have a role in the pathogenesis of both diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12947","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T07:42:55Z","timestamp":1501054975000},"page":"230-239","source":"Crossref","is-referenced-by-count":19,"title":["Idiopathic sudden sensorineural hearing loss and m\u00e9ni\u00e8re syndrome: The role of cerebral venous drainage"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-4228","authenticated-orcid":false,"given":"M. M.","family":"Ciccone","sequence":"first","affiliation":[{"name":"Section of Cardiovascular Diseases Department of Emergency and Organ Transplantation University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-0053","authenticated-orcid":false,"given":"P.","family":"Scicchitano","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases Department of Emergency and Organ Transplantation University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gesualdo","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases Department of Emergency and Organ Transplantation University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cortese","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases Department of Emergency and Organ Transplantation University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zito","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases Department of Emergency and Organ Transplantation University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Manca","sequence":"additional","affiliation":[{"name":"Department of Science of Educational, Psicology and Communication University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Boninfante","sequence":"additional","affiliation":[{"name":"P.J.D. of Statistical\u2010 Department of Medical Statistics University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Recchia","sequence":"additional","affiliation":[{"name":"Dipartimento di studi aziendali e giusprivatistici University \u201cA. Moro\u201d of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Leogrande","sequence":"additional","affiliation":[{"name":"Dipartimento di studi aziendali e giusprivatistici University \u201cA. Moro\u201d of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Viola","sequence":"additional","affiliation":[{"name":"Dipartimento di studi aziendali e giusprivatistici University \u201cA. Moro\u201d of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Damiani","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology Department of Basic Medical Science, Neuroscience and Sensory Organs University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Gambacorta","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology Department of Basic Medical Science, Neuroscience and Sensory Organs University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Piccolo","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology Department of Basic Medical Science, Neuroscience and Sensory Organs University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"De Ceglie","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology Department of Basic Medical Science, Neuroscience and Sensory Organs University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6214-2336","authenticated-orcid":false,"given":"N.","family":"Quaranta","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology Department of Basic Medical Science, Neuroscience and Sensory Organs University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812436449"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on hearing and equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease","volume":"113","author":"Committee on Hearing and Equilibrium","year":"2012","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31004-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2012.01.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111048"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(03)00077-8"},{"key":"e_1_2_8_8_1","first-page":"506","volume-title":"Pathology of the Ear","author":"Schuknecht HF","year":"1993"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0030-6665(20)30139-0","article-title":"Pathophysiologic theories in the etiology of M\u00e9ni\u00e8re's disease","volume":"30","author":"Gibson WP","year":"1997","journal-title":"Otolaryngol Clin North Am"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00019-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.11.027"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.10.024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720212800410849"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202610666131125000506"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs092"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050822"},{"key":"e_1_2_8_17_1","first-page":"5","volume-title":"The design and analysis of clinical experiments","author":"Fleiss JL","year":"1986"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2841-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0268355514526871"},{"key":"e_1_2_8_20_1","first-page":"1500","article-title":"The Craniocervical Venous System in Relation to Cerebral Venous Drainage","volume":"23","author":"San Mill\u00e1n Ru\u00edz D","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04804-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2008.07.006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03026011"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197004000-00007"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1954.7.3.245"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00285-014-0778-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2012.07.015"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2013.05.008"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.238535"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-009-9299-4"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132814Y.0000000397"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12947","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:41:28Z","timestamp":1695494488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,5]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/coa.12947"],"URL":"https:\/\/doi.org\/10.1111\/coa.12947","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,5]]}}}