{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:11:15Z","timestamp":1770538275874,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["MOST\u2010106\u20102314\u2010B418\u2010004"],"award-info":[{"award-number":["MOST\u2010106\u20102314\u2010B418\u2010004"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH \u2010 2016\u2010C\u2010042"],"award-info":[{"award-number":["FEMH \u2010 2016\u2010C\u2010042"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Nasopharyngeal cancer (<jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>) is an endemic disease in Taiwan. Prognostic factors the anatomical <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> stage are important for its prognostic stratification. An elevated neutrophil\u2010to\u2010lymphocyte ratio (<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>) has been reported to be associated with poor prognosis in various solid tumours. In this study, we analysed the prognostic impact of the <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Single\u2010institution retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Medical centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>One hundred and eighty patients with <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> treated at the Far Eastern Memorial Hospital, Taiwan, from January 2007 to December 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The association between the clinical or haematological presentations and the prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of the 180 patients included in this study were men (80%) and were &lt;65\u00a0years old (91.7%). A neck mass (55.6%) was the most common clinical presentation, followed by nasal (39.4%) and aural (30.6%) symptoms. In addition, the majority (75.4%) of patients had advanced stage (<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) disease. Patients with a high <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> (\u22673.6) had significantly lower progression\u2010free survival, overall survival and disease\u2010specific survival rates. The association between high <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> and poor prognosis was more pronounced in patients with advanced disease than in those with early\u2010stage <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>. The results of a multivariate analysis revealed that advanced age, clinical symptoms including headache, diplopia and facial numbness, advanced disease stage, and high <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> were independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> is an independent poor prognostic factor of <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> in Taiwan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12992","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T15:30:09Z","timestamp":1506439809000},"page":"463-469","source":"Crossref","is-referenced-by-count":21,"title":["Prognostic impact of pre\u2010treatment neutrophil\u2010to\u2010lymphocyte ratio (<scp>NLR<\/scp>) in nasopharyngeal carcinoma: A retrospective study of 180 Taiwanese patients"],"prefix":"10.1111","volume":"43","author":[{"given":"L.\u2010J.","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital New Taipei City Taiwan"},{"name":"Department of Electrical Engineering Yuan Ze University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.\u2010L.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Genomics Research Center Academia Sinica New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010T.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.\u2010C.","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.\u2010W.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.\u2010W.","family":"Shueng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Far Eastern Memorial Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010H.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Far Eastern Memorial Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010L.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan"},{"name":"Graduate Program in Biomedical Informatics Yuan Ze University Taiwan 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