{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:58:40Z","timestamp":1780084720390,"version":"3.54.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Gastroesophageal reflux recommended treatment (dose and duration) with proton\u2010pump inhibitor (PPI) compared to placebo significantly reduces the signs and symptoms of laryngopharyngeal reflux (LPR) and comorbid chronic rhinosinusitis (CRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Double\u2010blind randomised placebo\u2010controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Eight weeks of treatment with omeprazole 20 mg once daily (OD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Sixty patients (28 women, aged 19\u201087 years) with diagnosed LPR and comorbid CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Significant reduction in signs and symptoms (reflux symptom index (RSI) score as subjective, and reflux finding score (RFS) as objective measure) of LPR after 8 weeks of treatment with omeprazole 20 mg OD when compared to placebo. Secondary objectives were significant reduction in signs and symptoms of comorbid CRS after 8 weeks of treatment with omeprazole 20 mg OD when compared to placebo and the association of the severity of signs and symptoms of LPR with the ones of CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RSI and RFS decreased significantly more in the active treatment group after 8 weeks compared to placebo (<jats:italic>P<\/jats:italic> &lt; .001 for both). CRS and endoscopy scoring decreased both significantly more in the active group after 8 weeks compared to placebo (<jats:italic>P<\/jats:italic> &lt; .001 for both). CRS scoring significantly correlated with RSI (<jats:italic>R<\/jats:italic> = 0.312, <jats:italic>P<\/jats:italic> = .015) but not with RFS (<jats:italic>R<\/jats:italic> = 0.199, <jats:italic>P<\/jats:italic> = .127).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of our trial suggest that omeprazole 20 mg OD for 8 weeks was effective in reducing signs and symptoms of both LPR and CRS, although in most patients still present at the end of the trial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13005","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T06:52:40Z","timestamp":1507704760000},"page":"496-501","source":"Crossref","is-referenced-by-count":34,"title":["Eight weeks of omeprazole 20 mg significantly reduces both laryngopharyngeal reflux and comorbid chronic rhinosinusitis signs and symptoms: Randomised, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"43","author":[{"given":"S.A.","family":"Anzi\u0107","sequence":"first","affiliation":[{"name":"ENT Department Children's Hospital Srebrnjak Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Turkalj","sequence":"additional","affiliation":[{"name":"Department for Allergy and Pulmonology Children's Hospital Srebrnjak Zagreb Croatia"},{"name":"Faculty of Medicine J.J. Strossmayer University of Osijek Osijek Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"\u017dupan","sequence":"additional","affiliation":[{"name":"Department for Allergy and Pulmonology Children's Hospital Srebrnjak Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Labor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine J.J. Strossmayer University of Osijek Osijek Croatia"},{"name":"Department of Medicine University Hospital Center Osijek Osijek Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-8119","authenticated-orcid":false,"given":"D.","family":"Plavec","sequence":"additional","affiliation":[{"name":"Faculty of Medicine J.J. 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