{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:56:01Z","timestamp":1771480561318,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the distribution of the age of diagnosis of recurrent respiratory papillomatosis (<jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content>) and to determine the incidence and prevalence of <jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content> in both adults and children in the Free State province of South Africa in order to provide data from a population in sub\u2010Saharan African.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective record review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>All patients with RRP in the Free State province of South Africa between 2011 and 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Distribution of the age of diagnosis of <jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content> and incidence and prevalence of <jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The best fitting mixture distribution for the age of diagnosis of <jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content> was a two\u2010component mixture of log\u2010normal distributions. Within the first component (Jo<jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content>), the age of diagnosis was significantly lower in patients with human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>)11 disease (median 3.2\u00a0year) than those with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>6 disease (median 5.6\u00a0years) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.021), while in the second component (Ao<jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content>), there was no significant difference in the age of diagnosis between <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>11 disease (30.7\u00a0year) and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>6 disease (median 44.0\u00a0years) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0696).<\/jats:p><jats:p>The incidence and prevalence of Jo<jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content> were 1.34\/100000 population\/year and 3.88\/100000 population, respectively, while the incidence and prevalence of Ao<jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content> were 0.18\/100000 population\/year and 0.38\/100000 population, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recurrent respiratory papillomatosis in the Free State province of South Africa is a disease with a predominantly juvenile onset, with Ao<jats:styled-content style=\"fixed-case\">RRP<\/jats:styled-content> having a lower prevalence than in Europe. This is probably reflective of the situation in sub\u2010Saharan Africa.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13016","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T23:02:39Z","timestamp":1508540559000},"page":"533-537","source":"Crossref","is-referenced-by-count":36,"title":["Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis\u2014A South African perspective"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-334X","authenticated-orcid":false,"given":"R.Y.","family":"Seedat","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Health Sciences University of the Free State Bloemfontein Free State South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-3685","authenticated-orcid":false,"given":"R.","family":"Schall","sequence":"additional","affiliation":[{"name":"Statistical Consultation Unit Department of Mathematical Statistics and Actuarial Science University of the Free State Bloemfontein Free State South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.13.31"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12565"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23327"},{"key":"e_1_2_9_5_1","unstructured":"Statistics South Africa. 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