{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:14:02Z","timestamp":1761293642866,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Total laryngectomy is a well\u2010established treatment for locally advanced laryngeal cancer. Evidence for the benefit of post\u2010operative radiotherapy after laryngectomy in patients with locally advanced primaries and N0 or N1 nodal disease is limited. This study aimed to determine whether total laryngectomy alone is adequate therapy for certain patient subgroups with locally advanced laryngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We performed a retrospective survival analysis of patients in the surveillance epidemiology and end results (<jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content>) database with locally advanced laryngeal cancer between 2004 and 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome Measures<\/jats:title><jats:p>Primary outcome measure was overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For all patients with T3\u20104aN0\u20101 tumours, overall survival was worse for those treated with laryngectomy only when compared using the Kaplan\u2010Meier with a log\u2010rank test and when accounting for demographic and tumour data using a Cox multivariate regression. Other independent predictors of poor survival included age &gt;65\u00a0years old, Medicaid or uninsured payor status, supraglottic primary and N1 nodal disease. Stage\u2010 and subsite\u2010specific analysis revealed that patients with T4a primary tumours, N1 nodal disease and supraglottic subsite had worse overall survival when treated with laryngectomy alone. Alternatively, patients with T3 primary tumours, N0 nodal disease, glottic subsite had equivalent overall survival and disease\u2010specific survival when treated with laryngectomy alone vs laryngectomy with post\u2010operative radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Locally advanced laryngeal cancer patients with T3 primaries, no nodal disease or primaries of the glottis may not benefit from post\u2010operative radiotherapy when treated with primary total laryngectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13018","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T23:02:37Z","timestamp":1508540557000},"page":"544-552","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of laryngectomy alone for treatment of locally advanced laryngeal cancer: A stage\u2010 and subsite\u2010specific survival analysis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-3161","authenticated-orcid":false,"given":"B. P.","family":"Cervenka","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Division of Head and Neck Surgery University of California Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Oncology Division of Head and Neck Surgery University of California Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Farwell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Division of Head and Neck Surgery University of California Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. F.","family":"Bewley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Division of Head and Neck Surgery University of California Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"volume-title":"Cancer Facts and Figures","year":"2016","author":"Society AC","key":"e_1_2_9_2_1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900050021002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.4.370"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000236095.97947.26"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1671"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26357"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24443"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20477"},{"key":"e_1_2_9_11_1","unstructured":"BichakjianCK OlenckiT AasiS AlamMJ AndersenJ&BergD.Head and Neck Cancers Guidelines. 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