{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:59:40Z","timestamp":1740171580590,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Rhinology and Laryngology research charity","award":["HMPV"],"award-info":[{"award-number":["HMPV"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This prospective cohort study investigates the prediction of a voluntary cough using surface electromyography (<jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content>) of intercostal and diaphragm muscles, to develop control algorithms for an <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content>\u2010controlled artificial larynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The Ear Institute, London.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Electromyography onset compared to voluntary cough exhalation onset and to 100\u00a0ms (to give the artificial larynx the time to close the bioengineered vocal cords) before voluntary cough exhalation onset, in twelve healthy participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 189 <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> of intercostal muscle\u2010detected voluntary coughs, 172 coughs (91% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 70\u2010112) were detected before onset of cough exhalation and 128 coughs (67.6% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 33.7\u2010101.7) 100\u00a0ms before onset of cough exhalation. In the 158 <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> of diaphragm muscle\u2010detected voluntary coughs, 149 coughs (94.3% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 76.3\u2010112.3) were detected before onset of cough exhalation and 102 coughs (64.6% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 26.6\u2010102.6) 100\u00a0ms before onset of cough exhalation. More coughs were detected before onset of cough exhalation when combining <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> activity of intercostal and diaphragm muscles and comparing this to intercostal muscle activity alone (183 coughs [96.8% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 83.8\u2010109.8] vs 172 coughs, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0294). When comparing the mentioned combination to diaphragm muscle activity alone, the higher percentage of detected coughs before cough exhalation onset was not found to be significant (183 coughs vs 149 coughs, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.295). In addition, more coughs were detected 100\u00a0ms before onset of cough exhalation with the mentioned combination of <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> activity and comparing this to intercostal muscles alone (149 coughs [78.8% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 48.8\u2010108.8] vs 128 coughs, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0198) and to diaphragm muscles alone (149 coughs vs 102 coughs, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most voluntary coughs can be predicted based on combined <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> signals of intercostal and diaphragm muscles, and therefore, these two muscle groups will be useful in controlling the bioengineered vocal cords within the artificial larynx during a voluntary cough.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13022","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T17:44:48Z","timestamp":1508953488000},"page":"562-566","source":"Crossref","is-referenced-by-count":2,"title":["Developing control algorithms of a voluntary cough for an artificial bioengineered larynx using surface electromyography of chest muscles: A prospective cohort study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0967-0206","authenticated-orcid":false,"given":"M.S.","family":"Banus","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck surgery The Ear Institute University College of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Birchall","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck surgery The Ear Institute University College of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Graveston","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck surgery The Ear Institute University College of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815a9ed3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1028-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.12.1270"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000032"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.06.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-003-7117-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/978-90-313-6360-5","volume-title":"Keel\u2010Neus\u2010Oorheelkunde En Hoofd\u2010Halschirurgie","author":"Huizing EH","year":"2007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23621"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9036-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.057901"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.6.1471"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.13022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T23:25:12Z","timestamp":1694906712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.13022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,23]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/coa.13022"],"URL":"https:\/\/doi.org\/10.1111\/coa.13022","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"type":"print","value":"1749-4478"},{"type":"electronic","value":"1749-4486"}],"subject":[],"published":{"date-parts":[[2017,11,23]]}}}