{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:14:56Z","timestamp":1790903696874,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the impact of nasal septal perforation (NSP) on quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Rhinology clinics from two hospitals in Liverpool, United Kingdom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients diagnosed with <jats:styled-content style=\"fixed-case\">NSP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Patients (n = 26) diagnosed with <jats:styled-content style=\"fixed-case\">NSP<\/jats:styled-content> completed the Sino\u2010Nasal Outcome Test\u201022 (<jats:styled-content style=\"fixed-case\">SNOT<\/jats:styled-content>\u201022). The collated data were compared with <jats:styled-content style=\"fixed-case\">SNOT<\/jats:styled-content>\u201022 scores from a cohort of healthy volunteers (n = 34) and a cohort of patients (n = 30) diagnosed with chronic rhinosinusitis (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean total <jats:styled-content style=\"fixed-case\">SNOT<\/jats:styled-content>\u201022 score of <jats:styled-content style=\"fixed-case\">NSP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> cohorts was higher than that observed in healthy volunteers. The mean total <jats:styled-content style=\"fixed-case\">SNOT<\/jats:styled-content>\u201022 score in the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> cohort (57.2, standard deviation <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 10.3) was the higher than <jats:styled-content style=\"fixed-case\">NSP<\/jats:styled-content> (50.2, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 23.5), although this difference did not achieve statistical significance. The mean score for the rhinologic\u2010specific domains (rhinologic symptoms, extranasal rhinologic symptoms), ear\/facial symptoms and psychological dysfunction domain was higher in the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> cohort compared to <jats:styled-content style=\"fixed-case\">NSP<\/jats:styled-content>, although statistical significance was only observed in the extranasal rhinologic symptoms domain (11.2, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 2.4 vs 6.4, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 4.1). Conversely, the mean sleep dysfunction domain score for <jats:styled-content style=\"fixed-case\">NSP<\/jats:styled-content> (12.7, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 7.5) was higher than <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> (10.0, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 4.9, respectively) although this was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study has assessed the clinimetric and psychometric properties of patients suffering from symptomatic <jats:styled-content style=\"fixed-case\">NSP<\/jats:styled-content>. Future reports should consider inclusion of <jats:styled-content style=\"fixed-case\">SNOT<\/jats:styled-content>\u201022 data but with the addition of perforation\u2010specific symptoms (nasal crusting, epistaxis, whistling noise).<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13031","type":"journal-article","created":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T15:22:36Z","timestamp":1510413756000},"page":"604-608","source":"Crossref","is-referenced-by-count":21,"title":["Sino\u2010Nasal Outcome Test\u201022 quality\u2010of\u2010life patterns in patients presenting with nasal septal perforation"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7213-0387","authenticated-orcid":false,"given":"S.C.","family":"Leong","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Aintree University Hospital NHS Foundation Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.J.","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Royal Liverpool and Broadgreen Hospitals NHS trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000224"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510700566X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1045"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.01.024"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4140"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12481"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin14.156"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23615"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2009.02.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221502761698720"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2007.01305.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25170"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.13031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T23:26:34Z","timestamp":1694906794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.13031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/coa.13031"],"URL":"https:\/\/doi.org\/10.1111\/coa.13031","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]}}}