{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:34:18Z","timestamp":1781019258442,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluation of outcome after curative treatment for sinonasal mucosal melanoma focused on the effect of adjuvant radiotherapy on recurrence and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective chart analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Fifty\u2010one patients with primary sinonasal mucosal melanoma who underwent surgical resection with curative intention between 1980 and 2016 at Erasmus Medical Center, Rotterdam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Patients were categorised into 2 groups: surgery alone and surgery with adjuvant radiotherapy. Log\u2010rank test was used to compare rates of recurrence and survival between treatment groups. Predictors for treatment modality, recurrence and survival were assessed with multivariate statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all patients<jats:italic>,<\/jats:italic> 23.5% developed local recurrence and 47.1% developed distant metastasis. Estimated 5\u2010year disease\u2010free survival was 25.2%, and 5\u2010year overall survival (OS) was 38.1%. Forty\u2010three patients (84.3%) were treated with post\u2010operative radiotherapy. Patients who underwent surgery with adjuvant radiotherapy presented more often with high tumour stage, tumour involving multiple sites and positive margins. Post\u2010operative radiotherapy seemed to be associated with better local control (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.549). No effect was found on occurrence of distant metastasis and OS. Positive margin status was an independent negative predictor for distant metastasis\u2010free survival and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our treatment outcomes are consistent with literature. Post\u2010operative radiotherapy seems to be associated with improved local control despite advanced disease and positive margin status in this treatment group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13033","type":"journal-article","created":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T14:42:37Z","timestamp":1511016157000},"page":"617-623","source":"Crossref","is-referenced-by-count":31,"title":["Adjuvant radiotherapy in sinonasal mucosal melanoma: A retrospective analysis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-6878","authenticated-orcid":false,"given":"C.J.I.","family":"Caspers","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center (EMC) Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.C.","family":"Dronkers","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center (EMC) Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7117-7300","authenticated-orcid":false,"given":"D.","family":"Monserez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center (EMC) Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"Wieringa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center (EMC) Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Baatenburg de Jong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center (EMC) Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.U.","family":"Hardillo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center (EMC) Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21925"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.05.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24435"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-608"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21558"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23355"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.8.864"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24652"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin11.267"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444500"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21831"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.20.2441"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0985-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90378-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21324"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2016.05.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1685-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24309"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1750-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283374d31"},{"key":"e_1_2_9_22_1","unstructured":"National Comprehensive Cancer Network.NCCN Guidelines Version 2.2016 head and neck cancers.2016.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf. 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