{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T18:23:19Z","timestamp":1782152599294,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Salivary gland neoplasms are rare tumours, with most arising in the parotid gland. Fine\u2010needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>) is a common method for preoperative evaluation of parotid masses, although its usefulness is controversial. This study was designed to evaluate the accuracy of <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> in a large cohort of patients, with emphasis on diagnosis of benign tumours and especially Warthin tumour which can be managed conservatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary medical centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>From 1991 to 2014, all patients 18 or older with both preoperative <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> and postoperative pathology report were included. Patients with a history of head and neck malignancy or chronic sialoadenitis and patients who had undergone prior oncological treatment were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>470 patients were available for analysis. Overall accuracy was 82.6%. Positive predictive value (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>) varied between 88.6% and 94.3% for pleomorphic adenoma and 77.1%\u2010100% for Warthin tumour, with values varying depending on different characteristics of patients (eg age, smoking status). For pathologically proven malignant tumours, the <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> diagnosis was benign or non\u2010diagnostic in 26% of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fine\u2010needle aspiration cytology has limited utility in confirming a benign diagnosis of a parotid mass for most patients, although for some subpopulations, the <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> may be high enough to defer surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13038","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T15:37:25Z","timestamp":1511797045000},"page":"632-637","source":"Crossref","is-referenced-by-count":22,"title":["Fine\u2010needle aspiration cytology for parotid lesions, can we avoid surgery?"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-4963","authenticated-orcid":false,"given":"Y.","family":"Shkedy","sequence":"first","affiliation":[{"name":"Departments of Otorhinolaryngology\u2010Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7957-5680","authenticated-orcid":false,"given":"U.","family":"Alkan","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology\u2010Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mizrachi","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology\u2010Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Shochat","sequence":"additional","affiliation":[{"name":"Departments of Medical Statistics Rabin Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Dimitstein","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Departments of Pathology &amp; 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