{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:47:39Z","timestamp":1772574459649,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the impact of age at diagnosis and other factors on survival in nasopharyngeal carcinoma (<jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Setting and Participants<\/jats:title><jats:p>A retrospective, population\u2010based cohort study of 3103 patients are selected, whose records were submitted to the Surveillance, Epidemiology, and End Results (<jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content>) database between 2004 and 2013. We evaluated the demographic and clinical characteristics of patients who were 20\u00a0years or older with a diagnosis of primary, non\u2010metastatic <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and risks of <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall survival rates at 1, 3, and 5\u00a0years were 85.8%, 71.0%, and 62.6%, respectively. Older age was a significant predictor of poor <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>, as was Chinese ethnicity. We also determined that middle\u2010aged white patients, but not middle\u2010aged black or Chinese patients, were at a higher risk of death than were younger patients of the same race\/ethnicity. Nodal (N) stage 0\u20101 disease was a significant predictor of poor <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> when comparing survival of older patients with N0\u20101 vs N2\u20103 stage disease. Finally, we found that married patients had a decreased risk of death when compared to those who were single.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The survival of older patients with <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> is inferior to that of younger patients. Race\/ethnicity, marital status, and stage of disease are important modifiers of risk. Collectively, our results indicate that management of older patients requires optimisation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13124","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T15:17:44Z","timestamp":1524583064000},"page":"1209-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Impact of age on survival of locoregional nasopharyngeal carcinoma: An analysis of the Surveillance, Epidemiology, and End Results program database, 2004\u20102013"],"prefix":"10.1111","volume":"43","author":[{"given":"S.\u2010J.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital 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