{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:49:42Z","timestamp":1769917782533,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Communaut\u00e9 Fran\u00e7aise de Belgique","award":["ARC N\u00b0AUWB-2012-12\/17-UMONS"],"award-info":[{"award-number":["ARC N\u00b0AUWB-2012-12\/17-UMONS"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the usefulness of voice quality measurements as a treatment outcome in patients with laryngopharyngeal reflux (LPR)\u2010related symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective uncontrolled multi\u2010centre study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A total of 80 clinically diagnosed LPR patients with a reflux finding score (RFS)&gt;7 and a reflux symptom index (RSI)&gt;13 were treated with pantoprazole and diet recommendations during 3 or 6\u00a0months, according to their evolution. RSI; RFS; blinded Grade, Roughness, Breathiness, Asthenia, Strain and Instability (GRBASI) and aerodynamic and acoustic measurements were evaluated at baseline, 3\u00a0months (n\u00a0=\u00a080), and 6\u00a0months (n\u00a0=\u00a041) post\u2010treatment. We conducted a correlation analysis between the adherence to the diet, and the evolution of both signs and symptoms and between videolaryngostroboscopic signs and acoustic measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reflux symptom index, RFS, perceptual voice quality evaluations (dysphonia, roughness, strain and instability), and aerodynamic and acoustic measurements (ie, percent jitter and percent shimmer) were significantly improved at 3\u00a0months post\u2010treatment but not at 6\u00a0months. Percent jitter was the most useful outcome for evaluating the clinical evolution of patients throughout the treatment course. A significant relationship between globus sensation and posterior commissure hypertrophy was documented; both seemed to significantly improve from 3 to 6\u00a0months. The correlation analysis revealed correlations between adherence to diet recommendations and the improvement of symptoms and between posterior commissure granulation severity and acoustic measurement impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Voice quality improved in a manner similar to both signs and symptoms throughout a 6\u2010month empirical treatment with better improvement the 3 first months. Voice quality assessments can be used as indicators of treatment effectiveness in patients with LPR\u2010related symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13140","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T23:17:10Z","timestamp":1526512630000},"page":"1273-1282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Change of signs, symptoms and voice quality evaluations throughout a 3\u2010 to 6\u2010month empirical treatment for laryngopharyngeal reflux disease"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J.R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Faculty of Medicine Laboratory of Anatomy and Cell Biology UMONS Research Institute for Health Sciences and Technology University of Mons (UMons) Mons Belgium"},{"name":"Faculty of Psychology Laboratory of 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