{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:41:57Z","timestamp":1790106117351,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital cytomegalovirus (<jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content>) infection is a major cause of sensorineural hearing loss in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective of review<\/jats:title><jats:p>The objective of this systematic review was to compare performance in paediatric cochlear implant users with <jats:styled-content style=\"fixed-case\">SNHL<\/jats:styled-content> caused by <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> compared to non\u2010<jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> implantees.<\/jats:p><\/jats:sec><jats:sec><jats:title>Type of review<\/jats:title><jats:p>Systematic review<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>PubMed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> and the Cochrane databases were searched from inception up to 15 May 2017 for children, cochlear implant, performance and their synonyms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evaluation methods<\/jats:title><jats:p>Titles, abstracts and full texts were screened for eligibility. Directness of evidence and risk of bias were assessed. From the included studies, study characteristics and outcome data (speech perception, speech production, receptive language and auditory performance of <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> groups and non\u2010<jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> groups) were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5280 unique articles were screened of which 28 were eligible for critical appraisal. After critical appraisal, 12 studies remained for data extraction. Seven of 12 studies showed worse performance after cochlear implantation in <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> children compared to non\u2010<jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> children. Worse performance in <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> children was attributed to <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content>\u2010related comorbidities in six of these studies. Available data on asymptomatic <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> children compared to non\u2010<jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> children did not reveal an unfavourable effect on cochlear implant performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The available evidence reveals that <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> children often have worse cochlear implant performance compared to non\u2010<jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> children, which can be attributed to <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> related comorbidities. We urge physicians to take into account the <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> related comorbidities in the counselling of paediatric <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> users deafened by <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13142","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T23:15:20Z","timestamp":1526512520000},"page":"1283-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cochlear implant performance in children deafened by congenital cytomegalovirus\u2014A systematic review"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-9731","authenticated-orcid":false,"given":"V.J.C.","family":"Kraaijenga","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and 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