{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:53:00Z","timestamp":1761562380944,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Spirometric evaluation of upper airway obstruction (<jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>) is not commonly performed by Otolaryngologists. In addition, functional evaluation of <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> by flow\u2010volume loops (<jats:styled-content style=\"fixed-case\">FVL<\/jats:styled-content>) is not available in all clinical settings. More recently, peak inspiratory flow (<jats:styled-content style=\"fixed-case\">PIF<\/jats:styled-content>) has proven to be a useful tool to monitor <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> at the patient's bedside. The aim of this work is to assess the role of <jats:styled-content style=\"fixed-case\">PIF<\/jats:styled-content> measured with a simple flow metre (In\u2010Check method) as a standardised, simple, non\u2010invasive tool in quantifying chronic and subacute <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> in a routine clinical practice. In addition, a Clinical <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> Questionnaire (<jats:styled-content style=\"fixed-case\">CCQ<\/jats:styled-content>), previously validated to assess the psychophysical status in patients with laryngotracheal stenosis, was utilised to evaluate respiratory function in <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Seventy 2 subjects, an <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> group of 26 patients and a control group of 46 healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The ability of <jats:styled-content style=\"fixed-case\">PIF<\/jats:styled-content> values to discriminate between the <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> group and the control group was assessed using a <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve. A Spearman rank correlation was used to test the relationship between <jats:styled-content style=\"fixed-case\">PIF<\/jats:styled-content> measurements and the global <jats:styled-content style=\"fixed-case\">CCQ<\/jats:styled-content> score. Additionally, an analysis of <jats:styled-content style=\"fixed-case\">CCQ<\/jats:styled-content> at domain and items levels was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peak inspiratory flow values were accurate, with an area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) of 0.98 (<jats:italic>P<\/jats:italic> &lt; .05) for differentiating the control group from the <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> group. A threshold <jats:styled-content style=\"fixed-case\">PIF<\/jats:styled-content> value of 170 L\/min was found for diagnosing <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>. An inconclusive negative trend was found (<jats:italic>r<\/jats:italic> = \u2212.19; <jats:italic>P<\/jats:italic> = .35) between <jats:styled-content style=\"fixed-case\">PIF<\/jats:styled-content> values and <jats:styled-content style=\"fixed-case\">CCQ<\/jats:styled-content> global score. Concerning <jats:styled-content style=\"fixed-case\">CCQ<\/jats:styled-content>, the symptoms domain was the most affected by <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>, higher than mental domains (<jats:italic>P<\/jats:italic> &lt; .001) as well as functional domains (<jats:italic>P<\/jats:italic> &lt; .01). Exertional dyspnoea and cough were the items that obtained the highest disturbed scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peak inspiratory flow is a non\u2010invasive, quantitative parameter to evaluate the severity of <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>. Testing can be easily performed in a routine clinical setting, with a non\u2010expensive hand\u2010held device, and could help medical follow\u2010up programmes and prevent emergency situations. However, <jats:styled-content style=\"fixed-case\">FVL<\/jats:styled-content> may be necessary for further assessment of <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> diseases. The <jats:styled-content style=\"fixed-case\">CCQ<\/jats:styled-content> confirms that exertional dyspnoea is the main symptom of <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>, but cough remains a common symptom.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13149","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T16:50:20Z","timestamp":1527180620000},"page":"1303-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Upper airway obstruction assessment: Peak inspiratory flow and clinical <scp>COPD<\/scp> Questionnaire"],"prefix":"10.1111","volume":"43","author":[{"given":"J.","family":"Sanchez\u2010Guerrero","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery Faculty Medicine Assistance Publique H\u00f4pitaux Paris (APHP) Sorbonne University Paris France"},{"name":"Department of Rehabilitation Faculty Medicine Assistance Publique H\u00f4pitaux Paris (APHP) Sorbonne University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Guerlain","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery Faculty Medicine Assistance Publique H\u00f4pitaux Paris (APHP) Sorbonne University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Samaha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery Faculty Medicine Assistance Publique H\u00f4pitaux Paris (APHP) Sorbonne University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery Faculty Medicine Assistance Publique H\u00f4pitaux Paris (APHP) Sorbonne University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lacau St Guily","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery Faculty Medicine Assistance Publique H\u00f4pitaux Paris (APHP) Sorbonne University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3412-0700","authenticated-orcid":false,"given":"S.","family":"P\u00e9ri\u00e9","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery Faculty Medicine Assistance Publique H\u00f4pitaux Paris (APHP) Sorbonne University Paris 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