{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:13:26Z","timestamp":1787948006795,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T00:00:00Z","timestamp":1535846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies illustrated that chronic rhinosinusitis and allergic rhinitis represent individual and socioeconomic burdens to a patient. However, few studies exist on the health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) amongst other rhinologic patients. Our study investigated the generic <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in different rhinologic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Unselected adult rhinologic patients requiring special care at the Helsinki University Hospital were enrolled in this cross\u2010sectional, questionnaire\u2010based prospective study in February, May, August and November 2014. Patients were mailed a medical history questionnaire and a generic 15\u2010dimension (15D) <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL questionnaire. Diagnostic data were collected from electronic patient records following outpatient visits. Patient <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL scores were compared to an age\u2010 and sex\u2010standardised general population sample obtained from a large national health examination survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study consisted of 337 rhinologic patients (mean age 50.2\u00a0years, 50.4% men). The mean 15D score amongst rhinologic patients (0.865) was both statistically significant and clinically poorer than that amongst the general population (0.929). Rhinologic patients fared poorly on most dimensions of the 15D instrument, particularly on sleep, discomfort and symptoms, breathing and vitality. Patients with obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) were particularly affected. Yet, comparing the five most common rhinologic diagnostic groups revealed no significant differences in the mean 15D scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rhinologic diseases, independent of the underlying cause, substantially and negatively affect patients\u2019 <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL. <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> decreases <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in these patients, although patients without an <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> diagnosis still suffer from a clinically important impairment of <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL and poor quality sleep.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13190","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T05:49:36Z","timestamp":1531288176000},"page":"1487-1493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Different rhinologic diseases cause a similar multidimensional decrease in generic health\u2010related quality of life"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-8432","authenticated-orcid":false,"given":"Maija","family":"Ylitalo\u2010Heikkil\u00e4","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Virkkula","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Sintonen","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto P.","family":"Roine","sequence":"additional","affiliation":[{"name":"Research Centre for Comparative Effectiveness and Patient Safety University of Eastern Finland Kuopio Finland"},{"name":"Group Administration University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija","family":"Hyt\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01712.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083953"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21370"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin15.400"},{"issue":"10","key":"e_1_2_8_8_1","first-page":"873","article-title":"Quality of life in patients with chronic rhinosinusitis and sleep dysfunction undergoing endoscopic sinus surgery: a pilot investigation of comorbid obstructive sleep apnea","volume":"141","author":"Alt JA","year":"2015","journal-title":"JAMA otolaryngology\u2013 head & neck surgery"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4297"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13356"},{"issue":"12","key":"e_1_2_8_11_1","first-page":"2497","article-title":"Does septoplasty enhance the quality of life in patients?","volume":"269","author":"Hytonen ML","year":"2012","journal-title":"EurArchOtorhinolaryngol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20824"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4272-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2012.3.0020"},{"key":"e_1_2_8_15_1","unstructured":"Finnish Local and Regional Authorities.Hospital Districts2018.https:\/\/www.kuntaliitto.fi\/sites\/default\/files\/media\/file\/Ervat_Sairaanhoitopiirit2017_0.pdf"},{"key":"e_1_2_8_16_1","unstructured":"KoskinenS&LundqvistA.Health functional capacity and welfare in Finland in 2011. 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