{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:56:03Z","timestamp":1778183763675,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Antibiotic prophylaxis is not indicated for clean head and neck surgery. However, its role in revision cases is not known. The objective was to prospectively test whether antibiotics are useful in this patient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a prospective, double\u2010blind, randomised, placebo\u2010controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A single\u2010centre study in a tertiary care centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>The patients were selected from a referred sample of adult patients (&gt;18 years old) who were planned to undergo revision clean head and neck surgery and who had no preoperative indication for prophylactic antibiotics (eg previous radiation therapy, tracheostomy, active infection, immunosuppression). A total of 59 patients were approached for the study. After exclusion, 53 were available for final analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>The intervention group received a single\u2010dose cefazolin, while the control group received placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcomes<\/jats:title><jats:p>The primary end\u2010point was the combined rate of surgical wound infection, bacteremia and sepsis. The secondary end\u2010points were length of hospital stay and drug\u2010induced adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 53 patients were randomised to 2 groups: 31 to antibiotics group and 22 to control group. There was no difference between the groups in baseline characteristics. The primary end\u2010point occurred in both groups at the same rate. There was no difference in secondary end\u2010point rate, as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prophylactic antibiotics appear to have no benefit in revision, clean head and neck surgery. Further studies in larger populations and other settings are needed.<\/jats:p><jats:p>(ClinicalTrials.gov number <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01980082, clinicaltrials.gov\/ct2\/show\/<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01980082).<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13195","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T07:23:11Z","timestamp":1532071391000},"page":"1508-1512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antibiotic prophylaxis in clean head and neck surgery: A prospective randomised controlled trial"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-4963","authenticated-orcid":false,"given":"Yotam","family":"Shkedy","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Rabin Medical Center, Petach Tikva Israel affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagit","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Rabin Medical Center, Petach Tikva Israel affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Nachalon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Rabin Medical Center, Petach Tikva Israel affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Rabin Medical Center, Petach Tikva Israel affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Menasherov","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Rabin Medical Center, Petach Tikva Israel affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Reifen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Rabin Medical Center, Petach Tikva Israel affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Shpitzer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Rabin Medical Center, Petach Tikva Israel affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000193183.30687.d5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199103000-00006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(99)70088-X"},{"key":"e_1_2_8_5_1","unstructured":"Scottish Intercollegiate Guidelines Network (SIGN).Antibiotics prophylaxis in surgery. 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