{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:19:23Z","timestamp":1779898763458,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In patients with nasal polyposis (<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>), otitis media with effusion (<jats:styled-content style=\"fixed-case\">OME<\/jats:styled-content>) seems to be a marker of severity of the inflammatory process occurring in those patients. The aim was to assess whether <jats:styled-content style=\"fixed-case\">OME<\/jats:styled-content> could represent a marker of resistance to the surgical treatment of <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Longitudinal observational cohort study including patients between January 1991 and January 2017. Mean follow\u2010up was 7.4 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary\u2010care hospital centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> who underwent surgery (radical bilateral sphenoethmoidectomy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Four outcomes reflecting resistance to the surgical treatment: a clinical score of rhinologic symptoms, the mean number of systemic corticosteroids treatment per year, the recurrence rate of polyps and the rate of reoperation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 266 patients were included (63.9% of men, mean age 48 years). In multivariate linear mixed\u2010effects regression, when compared to patients without <jats:styled-content style=\"fixed-case\">OME<\/jats:styled-content>, patients with <jats:styled-content style=\"fixed-case\">OME<\/jats:styled-content> presented a similar clinical score of symptoms (coefficient 0.09, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) \u22120.25 to 0.06, <jats:italic>P<\/jats:italic>\u2010value = 0.24) and a borderline higher mean number of systemic corticosteroids treatments per year (coefficient 0.11, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.003\u20100.23, <jats:italic>P<\/jats:italic>\u2010value = 0.04). In multivariate Cox regression analyses, patients with <jats:styled-content style=\"fixed-case\">OME<\/jats:styled-content> had a similar reoperation rate than patients without <jats:styled-content style=\"fixed-case\">OME<\/jats:styled-content> (hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 0.29, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.06\u20101.50) and a similar recurrence rate of polyps (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.59, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.23\u20101.53).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OME<\/jats:styled-content> is not a marker of surgical resistance. Those patients should be managed similarly than patients without, and similar outcomes following surgery should be expected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13201","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T08:17:13Z","timestamp":1532938633000},"page":"1522-1527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Otitis media with effusion in nasal polyposis and outcomes following surgery: A longitudinal observational study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-6145","authenticated-orcid":false,"given":"Q.","family":"Lisan","sequence":"first","affiliation":[{"name":"Faculty of Medicine Paris Descartes University Paris France"},{"name":"Department of Head and Neck Surgery Georges Pompidou European Hospital Paris France"},{"name":"Department of Epidemiology INSERM UMR\u2010S970 Paris 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