{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:08:32Z","timestamp":1790345312391,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the olfactory bulb volumes (<jats:styled-content style=\"fixed-case\">OBV<\/jats:styled-content>s) in patients with chronic rhinosinusitis with nasal polyps (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>) to healthy individuals, and to assess the changes of the <jats:styled-content style=\"fixed-case\">OBV<\/jats:styled-content>s in patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> before and after the endoscopic sinus surgery (<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>) utilising magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) with specialised software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This is a prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tanta University hospital (tertiary referral hospital), Egypt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Thirty patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> (Group A) were compared with thirty healthy individuals (Group B) as regards the <jats:styled-content style=\"fixed-case\">OBV<\/jats:styled-content>s. Patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> underwent <jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content> where the Smell Identification Test\u201040 (<jats:styled-content style=\"fixed-case\">SIT<\/jats:styled-content>\u201040) and the <jats:styled-content style=\"fixed-case\">OBV<\/jats:styled-content>s were assessed pre\u2010operatively and at least 6\u00a0months postoperatively. Assessment of the <jats:styled-content style=\"fixed-case\">OBV<\/jats:styled-content>s was carried out using <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> with specialised software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Assessment of the volumetric changes of the olfactory bulbs in patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> before and after endoscopic sinus surgery utilise magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">OBV<\/jats:styled-content>s were significantly smaller in Group A (58.94\u00a0\u00b1\u00a07.96\u00a0mm<jats:sup>3<\/jats:sup> and 60.79\u00a0\u00b1\u00a08.14\u00a0mm<jats:sup>3<\/jats:sup> on the right and left sides, respectively) as compared with the Group B (73.46\u00a0\u00b1\u00a08.54\u00a0mm<jats:sup>3<\/jats:sup> and 72.96\u00a0\u00b1\u00a09.74\u00a0mm<jats:sup>3<\/jats:sup> on the right and left sides, respectively). There was also a significant increase in the olfactory bulb volumes as well as improvement of the <jats:styled-content style=\"fixed-case\">SIT<\/jats:styled-content>\u201040 6\u00a0months postoperatively in the Group A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The olfactory bulb is characterised by neural plasticity, and its volume may be affected by the peripheral olfactory function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13202","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T08:14:44Z","timestamp":1532938484000},"page":"1528-1534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Olfactory bulb neuroplasticity: A prospective cohort study in patients with chronic rhinosinusitis with nasal polyps"],"prefix":"10.1111","volume":"43","author":[{"given":"E.M.","family":"Shehata","sequence":"first","affiliation":[{"name":"Otolaryngology\/Head 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