{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:28:33Z","timestamp":1769228913207,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to compare quality of life (<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) in small unilateral vestibular schwannoma (<jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content>) patients managed by microsurgery, radiotherapy or observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>A retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included a total of 142 patients with <jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content> stage 1 or 2 according to the Koos classification and treated between January 2004 and December 2015. Microsurgery, radiotherapy and observation groups comprised 43, 46 and 53 patients, respectively. All patients completed four <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> (questionnaires: Short\u2010Form Health Survey 36, Hearing Handicap Inventory, Tinnitus Handicap Inventory and Dizziness Handicap Inventory Short\u2010Form). Clinical symptoms and <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> were compared among groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average time interval between management and filling in the questionnaires was 66\u00a0months. There was no difference in <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> between the three groups on any of the four questionnaires. The most debilitating symptom was vertigo for all three groups. Tinnitus was a pejorative factor in the surgery group. Hearing level was deteriorated after microsurgery but there was no significant difference between the radiotherapy group and the middle fossa approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with small <jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content> stage 1 and 2 had similar <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>, irrespective of management by observation, radiotherapy or microsurgery. The overall predictor for long\u2010term reduced <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> was vertigo. Vestibular rehabilitation could improve <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> in symptomatic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13203","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T11:55:17Z","timestamp":1532951717000},"page":"1478-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Quality of life in the management of small vestibular schwannomas: Observation, radiotherapy and microsurgery"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5913-5688","authenticated-orcid":false,"given":"Sarah","family":"Deberge","sequence":"first","affiliation":[{"name":"Service ORL CHU de Rennes facult\u00e9 de M\u00e9decine de Rennes Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anais","family":"Meyer","sequence":"additional","affiliation":[{"name":"Service ORL CHU de Rennes facult\u00e9 de M\u00e9decine de Rennes Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estelle","family":"Le Pabic","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique et Biologique CHU de Rennes facult\u00e9 de M\u00e9decine de Rennes Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Peigne","sequence":"additional","affiliation":[{"name":"Service ORL CHU de Rennes facult\u00e9 de M\u00e9decine de Rennes Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Morandi","sequence":"additional","affiliation":[{"name":"Service de Neurochirurgie CHU de Rennes facult\u00e9 de M\u00e9decine de Rennes Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Godey","sequence":"additional","affiliation":[{"name":"Service ORL CHU de Rennes facult\u00e9 de M\u00e9decine de Rennes Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3181f22660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2011.12.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.12.JNS111662"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31819a8df6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01401974"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700110"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988509300202"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00081-X"},{"key":"e_1_2_10_10_1","first-page":"37","article-title":"Identification of elderly people with hearing problems","volume":"25","author":"Ventry IM","year":"1983","journal-title":"ASHA"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2009.12.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-199905000-00009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2008.10.JNS081014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814524531"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000219217.14930.14"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.11.JNS14594"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.05.009"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000340684.60443.55"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000885"},{"key":"e_1_2_10_20_1","first-page":"1725","article-title":"[Vestibular schwannoma (acoustic neurinoma). 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