{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:14:49Z","timestamp":1780078489096,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The literature on nasopharyngeal carcinoma survival in the United States has focused mostly on Whites or Asians and not much is known about survivorship in other minority racial and ethnic groups. We aimed to determine the disease\u2010specific survival rate and prognostic factors for nasopharyngeal carcinoma survival across the minority United States population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The Surveillance, Epidemiology and End Results (<jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content>) 13 database from 1992 to 2014 was queried for adult cases of nasopharyngeal carcinoma (<jats:italic>n<\/jats:italic> = 2549).<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Eligible cases were Blacks, Hispanics, Asians\/Pacific Islanders, American Indians\/Alaska Natives; White patients were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcomes Measure<\/jats:title><jats:p>A multivariable competing risk survival analysis yielded hazard ratios (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) for competing mortality and was used to identify independent prognostic factors for survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010Hispanic American Indians\/Alaska Natives consistently had the worst cause\u2010specific survival of any group and that non\u2010Hispanic Asians\/Pacific Islanders consistently had the best survival (<jats:italic>P<\/jats:italic> &lt; 0.001). Even after adjusting for other poor prognostic factors in the study, including older age, keratinising histology, and lack of radiation treatment, non\u2010Hispanic American Indians\/Alaska Natives had more than double hazards of death from nasopharyngeal cancer compared with non\u2010Hispanic Asians\/Pacific Islanders (<jats:styled-content style=\"fixed-case\">aHR<\/jats:styled-content> = 2.63, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.67, 4.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are disparities in nasopharyngeal carcinoma survival among racial and ethnic minority groups in the United States, with American Indians\/Alaskan Natives faring worst. It is critical that future research focuses on nasopharyngeal carcinoma among this population to improve survivorship and mitigate cancer\u2010related health disparities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13225","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T09:30:06Z","timestamp":1537090206000},"page":"14-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Survival differences in nasopharyngeal carcinoma among racial and ethnic minority groups in the United States: A retrospective cohort study"],"prefix":"10.1111","volume":"44","author":[{"given":"Sai D.","family":"Challapalli","sequence":"first","affiliation":[{"name":"Saint Louis University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Saint Louis University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Adjei Boakye","sequence":"additional","affiliation":[{"name":"Saint Louis University Center for Health Outcomes Research St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Saint Louis University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jastin L.","family":"Antisdel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Saint Louis University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Saint Louis University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-9753","authenticated-orcid":false,"given":"Nosayaba","family":"Osazuwa\u2010Peters","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Saint Louis University School of Medicine St. Louis Missouri"},{"name":"Saint Louis University Cancer Center St. Louis Missouri"},{"name":"Department of Epidemiology Saint Louis University College for Public Health and Social Justice St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Union of International Cancer Control (UICC).Nasopharyngeal carcinoma. 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