{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T14:48:22Z","timestamp":1782571702797,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3D0771"],"award-info":[{"award-number":["CMRPG3D0771"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001236","name":"Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3D0771"],"award-info":[{"award-number":["CMRPG3D0771"]}],"id":[{"id":"10.13039\/100001236","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between baseline snoring sound energy (SSE) and disease severity, changes in SSE after adenotonsillectomy, and the predictors of surgical success in children with obstructive sleep apnoea (OSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral medical centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Thirty\u2010two children with OSA whose apnoea\u2010hypopnoea index \u22655 or apnoea\u2010hypopnoea index \u22651.5 with OSA comorbidities were recruited. Patients with complicated OSA were excluded. All participants underwent snoring sound analysis, polysomnography, and adenotonsillectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Snoring sound energy and apnoea\u2010hypopnoea index were assessed at baseline and 6\u00a0months after adenotonsillectomy. Surgical success was defined as a postoperative apnoea\u2010hypopnoea index &lt;1.5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age, body mass index, and apnoea\u2010hypopnoea index was 9\u00a0years, 19.0\u00a0kg\/m<jats:sup>2<\/jats:sup>, and 13.2\u00a0events\/h, respectively. Multivariate logistic regression showed that a baseline tonsil size of IV (odds ratio 15.7 [95% CI: 1.5\u2010166.3]) and SSE of 801\u20101000\u00a0Hz\u00a0&gt;\u00a021.9\u00a0dB (odds ratio 32.3 [95% CI: 2.6\u2010396.6]) were significantly related to severe OSA. Following adenotonsillectomy, apnoea\u2010hypopnoea index decreased significantly (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.001). SSE of 41\u2010200\u00a0Hz, 201\u2010400\u00a0Hz and 801\u20101000\u00a0Hz also decreased significantly (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.04, 0.01 and 0.006, respectively). Baseline SSE of 801\u20101000\u00a0Hz\u00a0&lt;\u00a08.5\u00a0dB significantly predicted surgical success (odds ratio 11.0 [95% CI: 1.4\u201085.2]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest the potential utility of SSE of 801\u20101000\u00a0Hz to screen for severe OSA, predict surgical success and assess therapeutic outcomes. Specific baseline SSE may represent a potential biomarker for childhood OSA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13231","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T14:37:46Z","timestamp":1538059066000},"page":"47-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Snoring sound energy as a potential biomarker for disease severity and surgical response in childhood obstructive sleep apnoea: A pilot study"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0959-9393","authenticated-orcid":false,"given":"Chun\u2010Ting","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Sleep Center Linkou Chang Gung Memorial Hospital Taoyuan 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