{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:50:48Z","timestamp":1783050648814,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007275","name":"Ministry of Science and Technology of Thailand","doi-asserted-by":"publisher","award":["MOST 105-2314-B-182A-070-MY2"],"award-info":[{"award-number":["MOST 105-2314-B-182A-070-MY2"]}],"id":[{"id":"10.13039\/501100007275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG5F0091-3 and CMRPG3C0461-4"],"award-info":[{"award-number":["CMRPG5F0091-3 and CMRPG3C0461-4"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Neuromuscular control, glottal conformation and aerodynamics are the major factors affecting voice performance. We aimed to characterise the degree to which voice improvements following office\u2010based intracordal hyaluronate injection laryngoplasty (HIL) depend on changes in voice aerodynamics in patients with unilateral vocal fold paralysis (UVFP), by assessing the correlations between these parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Otolaryngology Clinics in a Medical Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with UVFP within 6\u00a0months of their first outpatient visit who received single HIL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Videolaryngostroboscopy, aerodynamics and laboratory voice analysis were evaluated at baseline and 1\u00a0month after HIL. Quantitative laryngeal electromyography was evaluated at baseline to confirm UVFP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five newly diagnosed patients with UVFP were analysed. The normalised glottal gap area (NGGA) decreased (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) (Cohen's <jats:italic>d<jats:sub>z<\/jats:sub><\/jats:italic>\u00a0=\u00a00.94) and all aerodynamic parameters improved (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) (Cohen's <jats:italic>d<jats:sub>z<\/jats:sub><\/jats:italic>\u00a0=\u00a00.38\u20101.02) following HIL. Patients undergoing thoracic surgery had more profound aerodynamic impairments both before and after HIL. After adjusting for improvements in NGGA, the improvement in aerodynamics was correlated with voice improvement and most notably with maximum phonation time and jitter\/shimmer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hyaluronate injection laryngoplasty improved glottal conformation, aerodynamics and voice, highlighting the benefit of early HIL intervention for patients with UVFP. Patients with UVFP caused by thoracic surgery continued to have poorer aerodynamics post\u2010HIL, indicating the importance of speech therapy in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13343","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T12:28:50Z","timestamp":1555763330000},"page":"594-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Voice aerodynamics following office\u2010based hyaluronate injection laryngoplasty"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5986-0046","authenticated-orcid":false,"given":"Yu\u2010Cheng","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan"},{"name":"School of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Healthy Aging Research Center Chang Gung University Taoyuan Taiwan"},{"name":"Center of Vascularized Tissue Allograft Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Feng","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice M. 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