{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:58:40Z","timestamp":1780084720372,"version":"3.54.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1A2A2A05005220"],"award-info":[{"award-number":["2016R1A2A2A05005220"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002462","name":"Chungnam National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2016R1A2A2A05005220"],"award-info":[{"award-number":["2016R1A2A2A05005220"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Proton\u2010pump inhibitor (PPI) prescribing practices in laryngopharyngeal reflux disease (LPR) differ among physicians. We assessed the improvement in reflux symptom index (RSI) and reflux finding score (RFS) after treating LPR with three different regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective, double\u2010blind, randomized clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Chungnam national university hospital in Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>From July 2015 to July 2017, 100 patients with LPR included in the study. The patients were prescribed one of the following regimens for 3\u00a0months: group A, ilaprazole 10\u00a0mg, once a day (QD), n\u00a0=\u00a029; group B, ilaprazole 10\u00a0mg, twice a day (BID), n\u00a0=\u00a027; and group C, ilaprazole 10\u00a0mg BID plus mosapride citrate 5\u00a0mg three times a day (TID), n\u00a0=\u00a044.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The total RSI and RFS scores and each subitems in RSI and FRS of the patients were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total RFS and RSI scores improved significantly at the 3\u2010month follow\u2010up in all groups, and the improvements were of similar magnitudes. Regarding the RFS, the degrees of improvement in vocal cord oedema (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and diffuse laryngeal oedema (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) scores differed significantly among the three groups. Moreover, overweight or obese patients in group C showed the greatest improvement in RFS. However, age had no effect on treatment efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Three PPI therapeutic strategies showed similar efficacies against LPR according to total RFS and RSI scores. The addition of a prokinetic resulted in improvements in specific endoscopic findings, such as vocal cord oedema and diffuse laryngeal oedema. Furthermore, the addition of a prokinetic to PPI therapy was particularly beneficial for overweight or obese patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13345","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T15:23:45Z","timestamp":1555687425000},"page":"612-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of three proton\u2010pump inhibitor therapeutic strategies on laryngopharyngeal reflux disease; a prospective randomized double\u2010blind study"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-2470","authenticated-orcid":false,"given":"Young Hoon","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Research Institute for Medical Sciences, School of Medicine Chungnam National University Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Wan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Research Institute for Medical Sciences, School of Medicine Chungnam National University Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Research Institute for Medical Sciences, School of Medicine Chungnam National University Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Sung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Research Institute for Medical Sciences, School of Medicine Chungnam National University Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Won","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Research Institute for Medical Sciences, School of Medicine Chungnam National University Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-0006","authenticated-orcid":false,"given":"Bon Seok","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Research Institute for Medical Sciences, School of Medicine Chungnam National University Daejeon 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