{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:23:01Z","timestamp":1767165781273,"version":"build-2238731810"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the potential role of maternal serum concentrations of placental growth hormone variant (GH\u2010V), insulin\u2010like growth factor (IGF) 1 and 2, and IGF\u2010binding proteins (IGFBP) 1 and 3 in pregnancies complicated by otosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Otosclerosis cases (n\u00a0=\u00a022) and age, ethnicity\u2010matched controls (n\u00a0=\u00a022) were selected in a nested case\u2010control study. Maternal serum hormone concentrations at 26 and 34\u00a0weeks of gestation were determined by enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Concentrations of all measured hormones except IGFBP\u20101 were increased as gestation progressed. Maternal serum GH\u2010V concentrations at 26 and 34\u00a0weeks of gestation were significantly increased in the otosclerosis group, when compared to the control group (2.53\u00a0\u00b1\u00a00.17\u00a0ng\/ml vs. 1.78\u00a0\u00b1\u00a00.19\u00a0ng\/ml,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.036; 4.34\u00a0\u00b1\u00a00.31\u00a0ng\/ml vs. 3.12\u00a0\u00b1\u00a00.18\u00a0ng\/ml,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, respectively). Maternal serum IGF\u20101 concentrations at 34\u00a0weeks in otosclerotic patients were significantly higher than in the controls (589.1\u00a0\u00b1\u00a021.4\u00a0ng\/ml vs. 499.7\u00a0\u00b1\u00a017.8\u00a0ng\/ml,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The increase of IGF\u20101 was not observed at 26\u00a0weeks of gestation. Serum IGF\u20102, IGFBP\u20101 and IGFBP\u20103 at either 26 or 34\u00a0weeks were unaltered between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal serum concentrations of GH\u2010V and IGF\u20101 were altered in pregnancy complicated by otosclerosis, suggesting that the GH\u2010IGF axis may contribute to the development of this condition during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.13385","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T04:45:05Z","timestamp":1559277905000},"page":"757-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Retracted:<\/i>\n                    Increased maternal serum placental growth hormone variant in pregnancies complicated by otosclerosis"],"prefix":"10.1111","volume":"44","author":[{"given":"Shutan","family":"Liao","sequence":"first","affiliation":[{"name":"Rural Clinical School University of New South Wales Sydney New South Wales Australia"},{"name":"The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Lu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangliang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of ENT The First Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7176-6500","authenticated-orcid":false,"given":"Ruiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of ENT The First Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200103000-00023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198404000-00015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.07.014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600207"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1983.tb01428.x"},{"issue":"5","key":"e_1_2_9_7_1","first-page":"465","article-title":"The incidence of otosclerosis in the general population","volume":"11","author":"Gapany\u2010Gapanavicius B","year":"1975","journal-title":"Isr J Med Sci"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1982.tb01393.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1979.tb01898.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000187573.99335.85"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.03.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(01)00176-7"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"59","article-title":"The human growth hormone gene locus: structure, evolution, and allelic variations","volume":"6","author":"Hirt H","year":"1987","journal-title":"DNA\u2010J Molec Cell Bio"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147167"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32834c800d"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(98)00040-9"},{"key":"e_1_2_9_17_1","article-title":"Growth hormone deficiency and pregnancy: any role for substitution?","author":"Vila G","year":"2018","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.1.35"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00312829"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000511784.21936.1b"},{"key":"e_1_2_9_21_1","first-page":"6","article-title":"Prevalence of histologic otosclerosis: an unbiased temporal bone study in Caucasians","volume":"65","author":"Declau F","year":"2007","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","unstructured":"LiaoS VickersMH TaylorRS et al. 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