{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:32:05Z","timestamp":1768314725508,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T00:00:00Z","timestamp":1572134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate the bone mineral density (BMD) in a group of Swedish patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) with or without asthma, as well as to evaluate whether the treatment of this patient group is in accordance with the EPOS recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, settings and participants<\/jats:title><jats:p>Adult patients with a diagnosis of CRSwNP, and a history of at least two courses of oral corticosteroids (OCS) during the last year, were consecutively included in this study at five centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The BMD of the patients was measured by Dual\u2010energy X\u2010ray absorptiometry (DXA), which is the only technology for classifying BMD according to the criteria established by WHO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 51 patients, with an average number of 7\u00a0years with OCS treatment, were enrolled. During the last 12\u00a0months, the mean number of OCS courses was 2.76, and the total mean intake was 891\u00a0mg of Prednisone equivalents. According to the T\u2010scores, 17 patients were measured to have \u2264\u22121 SD T\u2010score lumbar spine, which is considered to be osteopenia, and five patients had &lt;\u22122.5 SD T\u2010score, considered as osteoporosis. However, when taking age and gender into account and analysing the Z\u2010scores, only 2 patients had a reduced density of the spine and none in the hip, which is no difference compared to a matched Swedish population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This prospective study shows that 2\u20103 moderate courses of OCS annually may be used without high risk of causing osteopenia\/osteoporosis in patients with CRSwNP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13431","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T15:08:40Z","timestamp":1568732920000},"page":"1011-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does the oral steroid treatment of patients with nasal polyposis cause osteopenia or osteoporosis?"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5146-3636","authenticated-orcid":false,"given":"Pernilla","family":"Sahlstrand\u2010Johnson","sequence":"first","affiliation":[{"name":"Department of Oto\u2010Rhino\u2010Laryngology, Head and Neck Surgery Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Intervention and Technology Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Ehnhage","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Intervention and Technology Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01828.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200709"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.4.717"},{"key":"e_1_2_8_5_1","unstructured":"FokkensWJ et al.European position paper on rhinosinusitis and nasal polyposis. 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