{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:12Z","timestamp":1787014032529,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>High definition laryngoscopy (HDL) could lead to better interpretation of the pharyngeal and laryngeal mucosa than regularly used fiberoptic laryngoscopy (FOL). The primary aim of this study is to quantify the diagnostic advantage of HDL over FOL in detecting mucosal anomalies in general, in differentiating malignant from benign lesions and in predicting specific histological entities. The secondary aim is to analyse image quality of both laryngoscopes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective paired analysis with multiple observers evaluating endoscopic videos simulating daily clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A tertiary referral hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>In 36 patients, both FOL and HDL videos were obtained. Six observers were provided with additional clinical information, and 36 FOL and HDL videos were evaluated in a randomised order.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Sensitivity, specificity, positive and negative predictive value and diagnostic accuracy of observers using both flexible laryngoscopes were calculated for detection of mucosal lesions in general and uncovering malignant lesions. Sensitivities were calculated for prediction of specific histological entities. Image quality (scale 1\u201010) was assessed for both flexible laryngoscopes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HDL reached higher sensitivity compared to FOL for detection of mucosal abnormalities in general (96.0% vs 90.4%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03), differentiating malignant from benign lesions (91.7% vs 79.8%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03) and prediction of specific histological entities (59.7% vs 47.2%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Image quality was judged better with HDL in comparison with FOL (mean: 8.4 vs 5.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HDL is superior to FOL in detecting mucosal anomalies in general, malignancies and specific histological entities. Image quality is considered as superior using HDL compared to FOL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.13476","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T12:17:10Z","timestamp":1574252230000},"page":"119-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Differences in the diagnostic value between fiberoptic and high definition laryngoscopy for the characterisation of pharyngeal and laryngeal lesions: A multi\u2010observer paired analysis of videos"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-0472","authenticated-orcid":false,"given":"Constanze","family":"Scholman","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen M.","family":"Westra","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6825-7932","authenticated-orcid":false,"given":"Manon A.","family":"Zwakenberg","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5265-3722","authenticated-orcid":false,"given":"Frederik G.","family":"Dikkers","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-2260","authenticated-orcid":false,"given":"Gyorgy B.","family":"Halmos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-134X","authenticated-orcid":false,"given":"Jan","family":"Wedman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-0613","authenticated-orcid":false,"given":"Jan E.","family":"Wachters","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-2871","authenticated-orcid":false,"given":"Bernard F.A.M.","family":"van der Laan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8631-7727","authenticated-orcid":false,"given":"Boudewijn E.C.","family":"Plaat","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23630"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.01.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20146"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.07.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212101102"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/173039b0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2006.877110"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0549-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.01.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-19069-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"De GroenP.History of the endoscope. 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