{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:51:12Z","timestamp":1784692272720,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate in children the clinical severity and evolution of otogenic lateral sinus thrombosis (OLST) due to <jats:italic>Fusobacterium necrophorum<\/jats:italic> compared with other bacterial otogenic thrombosis and propose a specific management flowchart for <jats:italic>Fusobacterium<\/jats:italic> OLST.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective multicentre cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>Four French ENT paediatric departments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 260 under 18\u00a0years old admitted for acute mastoiditis were included. Initial imaging was reviewed to focus on complicated mastoiditis and 52 OLST were identified. Children were then divided into two groups according to bacteriological results: 28 in the \u201cOLST <jats:italic>Fusobacterium<\/jats:italic> group\u201d and 24 in the \u201cOLST other bacteria group\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant association between <jats:italic>F\u00a0necrophorum<\/jats:italic> and OLST (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). When compared to the OLST other bacteria group, children in the OLST <jats:italic>Fusobacterium<\/jats:italic> group were significantly younger (61\u00a0months vs 23\u00a0months, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) and had a more severe clinical presentation: higher CRP (113\u00a0mg\/L vs\u00a0175.7\u00a0mg\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) and larger subperiosteal abscess (14\u00a0mm vs 21\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Medical management was also more intensive in the OLST <jats:italic>Fusobacterium<\/jats:italic> group than in the OLST other bacteria group: increased number of conservative surgeries (66.7% vs 92.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) and longer hospital stay (13.7\u00a0days vs 19.8\u00a0days, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). At the end of follow\u2010up, the clinical course was good in both groups without any neurological sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thrombotic complications are very frequent in case of <jats:italic>Fusobacterium<\/jats:italic> mastoiditis and clinicians should be aware of the initial severity of the clinical presentation. Under appropriate management, the clinical course of <jats:italic>Fusobacterium<\/jats:italic> OLST is as good as that of other bacterial otogenic thrombosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13478","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T10:25:22Z","timestamp":1574245522000},"page":"182-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<i>Fusobacterium necrophorum<\/i>, a major provider of sinus thrombosis in acute mastoiditis: A retrospective multicentre paediatric study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-8214","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Coudert","sequence":"first","affiliation":[{"name":"Service d'ORL P\u00e9diatrique H\u00f4pital Femme M\u00e8re Enfants Hospices Civils de Lyon Lyon 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