{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:29:40Z","timestamp":1784302180466,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the effect of ventilation tube (VT) surgery on quality of life (QoL) in children with persistent otitis media with effusion (OME).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of trial data (oral steroids versus placebo for persistent OME), comparing QoL by history of VT surgery performed between 5\u00a0weeks and 12\u00a0months post\u2010randomisation. Multilevel regression models were used to identify the association between VT surgery and QoL scores at 12\u00a0months, controlling for pre\u2010exposure risk factors associated with surgery, including pre\u2010surgery hearing level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Ear, nose and throat (ENT), paediatric audiology and audiovestibular medicine (AVM) departments in Wales and England.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 327 children aged 2\u20108\u00a0years with OME symptoms for at least three months and audiometry\u2010proven bilateral hearing loss with VT surgery status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Otitis Media questionnaire (OM8\u201030) and Paediatric Quality of Life Inventory (PedsQL) total and subscale scores, and the Health Utilities Index Mark 3 (HUI3) at 12\u00a0months post\u2010randomisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants who had VT surgery had no significant difference in OM8\u201030, PedsQL or HUI total scores. OM8\u201030 hearing difficulty (HD) subscale scores at 12\u00a0months were better in those who had VT surgery (adjusted mean difference (aMD)\u00a0=\u00a0\u22120.46 (95% confidence interval: \u22120.69 to \u22120.23), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and this varied by when the surgery occurred (aMD for surgery between 5\u00a0weeks and 6\u00a0months\u00a0=\u00a0\u22120.4 [\u22120.67 to \u22120.13], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004 and between 6 and 12\u00a0months\u00a0=\u00a0\u22120.54, [\u22120.87 to \u22120.22], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ventilation tube surgery was associated with an improvement in HD\u2010related functional health status but no change in overall QoL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13502","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T17:05:01Z","timestamp":1577120701000},"page":"239-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of ventilation tube insertion on quality of life in children with persistent otitis media with effusion"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-6986","authenticated-orcid":false,"given":"Leigh N.","family":"Sanyaolu","sequence":"first","affiliation":[{"name":"The Division of Population Medicine Heath Park Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-6517","authenticated-orcid":false,"given":"Rebecca","family":"Cannings\u2010John","sequence":"additional","affiliation":[{"name":"The Centre for Trials Research Heath Park Cardiff 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