{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:27:47Z","timestamp":1777501667620,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hyperthyroidism (HT) has been associated with no insignificant rates of thyroid malignancy. There are no current specific guidelines that suggest routine preoperative imaging for thyroid nodules in patients with Grave's disease. We therefore performed a systematic review assessing rates of thyroid malignancy in patients undergoing surgery for different causes of HT: Grave's disease (GD), toxic adenoma (TA) and toxic multinodular goitre (TMNG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Major databases (MEDLINE, PubMed and the Cochrane library) were searched to identify eligible studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After searching and appraising, 33 papers were found to be eligible for analysis. The mean overall rate of malignancy was 8.5% (range 0.8%\u201032.4%). The mean rates based on histological subtype were as follows: papillary thyroid cancer (PTC), 3.1% (range 0%\u201013.2%); micropapillary carcinoma (mPTC), 5.1% (range 0%\u201016.9%); and follicular thyroid cancer (FTC), 0.8% (range 0%\u20104.4%). In those patients who had preoperative imaging, mean malignancy rates were higher in patients with pre\u2010identified nodules (19.8%) compared to those without any nodules (8.7%). Mean rates were lower in patients with GD\/diffuse goitre (5.9%) compared to patients with TA (6.5%) and TMNG (12%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hyperthyroidism is associated with notable rates of thyroid cancer, although the mechanisms for this are not clear. The presence of nodules increases this risk. This review raises the question for considering preoperative assessment of nodules in all patients undergoing surgery for HT, in order to correctly assess and evaluate any patients with suspected concurrent thyroid malignancy, before proceeding with surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13527","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T10:30:00Z","timestamp":1583749800000},"page":"538-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A systematic review of the incidence of thyroid carcinoma in patients undergoing thyroidectomy for thyrotoxicosis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0044-8094","authenticated-orcid":false,"given":"Kiran","family":"Varadharajan","sequence":"first","affiliation":[{"name":"ENT Specialist Registrar Royal Surrey County Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Choudhury","sequence":"additional","affiliation":[{"name":"ENT Consultant Surrey &amp; Sussex NHS Trust Redhill UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)32483-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30312-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01415.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14069"},{"key":"e_1_2_10_6_1","unstructured":"PRISMA.Reporting items for systematic reviews and meta\u2010analyses (PRISMA).http:\/\/www.prisma\u2010statement.org\/. Accessed August 01 2018."},{"key":"e_1_2_10_7_1","unstructured":"National heart lung and blood institute.Study quality assessment tools.https:\/\/www.nhlbi.nih.gov\/health\u2010topics\/study\u2010quality\u2010assessment\u2010tools. Accessed September 10 2018."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01504.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2012.06233.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860801)58:3<715::AID-CNCR2820580319>3.0.CO;2-P"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890301)63:5<908::AID-CNCR2820630520>3.0.CO;2-I"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800831206"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.12.006"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2005.04.009"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1988.tb03662.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000003569"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01415.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299741"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-7563.2007.00108.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01657662"},{"issue":"6","key":"e_1_2_10_21_1","first-page":"1148","article-title":"Thyroid carcinoma in Graves' disease","volume":"98","author":"Farbota LM","year":"1985","journal-title":"Surgery"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350115"},{"key":"e_1_2_10_23_1","first-page":"6","article-title":"Hyperthyroidism and concurrent thyroid malignancies","volume":"106","author":"Rieger R","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658550"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800801027"},{"key":"e_1_2_10_26_1","first-page":"217","article-title":"Cancer in hyperthyroidism","volume":"43","author":"Pomorski L","year":"1996","journal-title":"Neoplasma"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.8.2805"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.571"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089169908500407"},{"key":"e_1_2_10_30_1","first-page":"244","article-title":"Thyroid nodules in Graves' disease: implications in a endemically iodine deficient area","volume":"47","author":"Mishra A","year":"2001","journal-title":"J Postgrad Med"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/10507250252949432"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(09)70480-2"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0953-6205(03)00105-5"},{"issue":"2","key":"e_1_2_10_34_1","first-page":"79","article-title":"Thyroid cancer in patients with hyperthyroidism","volume":"60","author":"Gabriele R","year":"2003","journal-title":"Horm Res"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.08.022"},{"issue":"1","key":"e_1_2_10_36_1","first-page":"115","article-title":"Outcome of incidental thyroid carcinoma in patients undergoing surgery for Graves' disease","volume":"112","author":"D\u0103nil\u0103 R","year":"2008","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"issue":"4","key":"e_1_2_10_37_1","first-page":"325","article-title":"Malignancy rates in operated patients with hyperthyroidism in an area of endemic goiter","volume":"94","author":"Karagulle E","year":"2009","journal-title":"Int Surg"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-010-9405-6"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2287-z"},{"issue":"1","key":"e_1_2_10_40_1","first-page":"75","article-title":"Thyroid cancer in Grave's disease patients Abstracts","volume":"2","author":"Chinchuk I","year":"2013","journal-title":"Eur Thyroid J"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-013-1078-1"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-013-1078-1"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2014.04.013"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.04.025"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.7.11463"},{"issue":"1","key":"e_1_2_10_46_1","first-page":"P1","article-title":"15th international thyroid congress program and meeting abstracts","volume":"25","author":"Anaedo H","year":"2015","journal-title":"Thyroid"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10002-1162"},{"issue":"9","key":"e_1_2_10_48_1","first-page":"1154","article-title":"Frequency of thyroid nodules and differentiated thyroid cancer in Grave's disease. 86th annual meeting of the American thyroid association","volume":"26","author":"Hasanov R","year":"2016","journal-title":"Thyroid"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.13527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/coa.13527","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:54:54Z","timestamp":1694004894000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.13527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/coa.13527"],"URL":"https:\/\/doi.org\/10.1111\/coa.13527","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,20]]},"assertion":[{"value":"2018-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}