{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:40:47Z","timestamp":1777588847895,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the levels of endogenous \u03b11\u2010antitrypsin in the perilymph of patients undergoing cochlear implant (CI), and its reverse association with the severity of hearing loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>The study includes 38 patients undergoing CI surgery, 11 patients diagnosed with congenital deafness and 27 non\u2010congenital deafness, eight patients diagnosed with moderate hearing loss (N\u00a0=\u00a08; PTA\u00a0=\u00a070\u00a0dB), severe hearing loss (N\u00a0=\u00a011; PTA 70\u201090\u00a0dB) and profound hearing loss (N\u00a0=\u00a019; PTA\u00a0&gt;\u00a090\u00a0dB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome and measure<\/jats:title><jats:p>1 to 12\u00a0\u03bcL perilymphatic fluids were collected by micropipette. \u03b11\u2010antitrypsin levels were determined, and current and historic audiological parameters were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The congenital and non\u2010congenital group exhibited AAT concentrations of 2.5\u00a0\u00b1\u00a01.9\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> LFQ and 3.2\u00a0\u00b1\u00a01.2\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> LFQ, respectively (mean\u00a0\u00b1\u00a0SD; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.38). Mean levels of \u03b11\u2010antitrypsin in the perilymph fluid within the moderate group was 3.64\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup>\u00a0\u00b1\u00a02.1\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> LFQ vs 3.5\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup>\u00a0\u00b1\u00a01.2\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> in severe hearing loss (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.81) and 2.4\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup>\u00a0\u00b1\u00a01.1\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> LFQ in the profound hearings loss group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.06). The difference in levels of AAT in samples from the severe hearings loss group vs the profound hearings loss group reached statistical significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Insufficiency in \u03b11\u2010antitrypsin levels in the perilymph fluid of the inner ear appears to display a relationship with the severity of hearing loss. The prospect of introducing clinical\u2010grade plasma\u2010purified \u03b11\u2010antitrypsin directly onto the site of cochlear injury deserves thorough investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13541","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T08:04:25Z","timestamp":1585987465000},"page":"495-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Endogenous \u03b11\u2010antitrypsin levels in the perilymphatic fluid correlates with severity of hearing loss"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-7554","authenticated-orcid":false,"given":"Sabri","family":"El\u2010Saied","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Soroka University Medical Center Be\u2019er Sheva Israel"},{"name":"Department of clinical biochemistry and Pharmacology Faculty of Health Sciences Ben\u2010Gurion University of the Negev Be\u2019er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Head and Neck Surgery Hanover Medical University Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Durisin","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Head and Neck Surgery Hanover Medical University Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben\u2010Zion","family":"Joshua","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Soroka University Medical Center Be\u2019er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Abu Tailakh","sequence":"additional","affiliation":[{"name":"Recanati School for Community Health Professions, Department of Nursing, Faculty of Health Sciences Ben\u2010Gurion University of the Negev, Beer\u2010Sheva, Israel and Soroka University Medical Center Be\u2019er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Prenzler","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Head and Neck Surgery Hanover Medical University Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lenarz","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Head and Neck Surgery Hanover Medical University Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Soroka University Medical Center Be\u2019er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli C.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of clinical biochemistry and Pharmacology Faculty of Health Sciences Ben\u2010Gurion University of the Negev Be\u2019er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9652-1035","authenticated-orcid":false,"given":"Athanasia","family":"Warnecke","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Head and Neck Surgery Hanover Medical University Hannover 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