{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:01:31Z","timestamp":1790488891042,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Allergic rhinitis (AR) is a common inflammatory condition of the nasal mucosa affecting approximately 20% of the population worldwide. Current therapies include intranasal antihistamines, corticosteroids, subcutaneous and sublingual immunotherapy (SLIT). This review and meta\u2010analysis assess the efficacy of SLIT in the management of grass pollen\u2010induced AR in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ovid EMBASE, Ovid EBM Reviews, Cochrane Central Register of Controlled Trials, Ovid MedLine and PubMed were searched using the following terms: \u2018sublingual immunotherapy\u2019, \u2018SLIT\u2019, \u2018rhinitis\u2019, \u2018allergic rhinitis\u2019, \u2018rhinosinusitis\u2019 and \u2018rhino\u2010conjunctivitis\u2019. All included studies were double\u2010blind, placebo\u2010controlled and randomised trials. Primary outcome was symptom score and secondary outcome included quality of life and safety profile. Meta\u2010analysis of symptom improvement was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies were identified with 979 subjects randomly allocated to SLIT and 992 to a placebo control. All studies reported an improvement in symptoms with SLIT, with five reaching statistical significance (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Four studies reported statistically significant improvement in quality of life (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Oral pruritus was the most common adverse event reported. The overall risk of bias was high in 50% of the studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sublingual immunotherapy was a safe and effective treatment for grass pollen\u2010induced AR in adults, and therefore, consideration should be given to its use for moderate\u2010to\u2010severe disease in the UK\u2010wide population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13651","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T10:50:04Z","timestamp":1601117404000},"page":"52-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sublingual immunotherapy vs placebo in the management of grass pollen\u2010induced allergic rhinitis in adults: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-9947","authenticated-orcid":false,"given":"Dominika","family":"Boldovj\u00e1kov\u00e1","sequence":"first","affiliation":[{"name":"University of Aberdeen Medical School Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-438X","authenticated-orcid":false,"given":"Sara","family":"Cordoni","sequence":"additional","affiliation":[{"name":"University of Aberdeen Medical School Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-3044","authenticated-orcid":false,"given":"Craig John","family":"Fraser","sequence":"additional","affiliation":[{"name":"University of Aberdeen Medical School Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-877X","authenticated-orcid":false,"given":"Aimee Beth","family":"Love","sequence":"additional","affiliation":[{"name":"University of Aberdeen Medical School Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6260-3884","authenticated-orcid":false,"given":"Lorna","family":"Patrick","sequence":"additional","affiliation":[{"name":"University of Aberdeen Medical School Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3370-9051","authenticated-orcid":false,"given":"Gary James","family":"Ramsay","sequence":"additional","affiliation":[{"name":"University of Aberdeen Medical School Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-737X","authenticated-orcid":false,"given":"Aaron Stephen James","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Ninewells Hospital Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Gomati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology &amp; Head &amp; Neck Surgery Aberdeen Royal Infirmary Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Ram","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology &amp; Head &amp; Neck Surgery Aberdeen Royal Infirmary Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2016.04.009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00013904"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.12.002"},{"key":"e_1_2_11_5_1","unstructured":"National Institute for health and Care Excellence (NICE).Allergic rhinitis[Internet]. 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