{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:30:06Z","timestamp":1773984606904,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Given that 30%\u201050% of children with trisomy 21 have persistent obstructive sleep apnoea (OSA) after adenotonsillectomy, we evaluated whether demographic, clinical and polysomnographic factors predicted persistent OSA and OSA severity after adenotonsillectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Secondary care hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Retrospective review of 32 children with the diagnosis of trisomy 21 and OSA by polysomnography who underwent adenotonsillectomy, from January 2010 to December 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome and measure<\/jats:title><jats:p>Non\u2010parametric analysis was used to compare pre\u2010 and postoperative factors, and regression was used to model persistent OSA and OSA severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two children were included (17 males, median age 10.00\u00a0\u00b1\u00a08.00\u00a0years, median body mass index z\u2010score 0.89\u00a0\u00b1\u00a01.25). Overall, adenotonsillectomy resulted in a significant improvement in median obstructive apnoea\u2010hypopnoea index (oAHI) from 7.5\u00a0\u00b1\u00a08.95 to 4.40\u00a0\u00b1\u00a04.38 events per hour (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and in median OSA\u201018 score from 85.00\u00a0\u00b1\u00a012.00 to 61.00\u00a0\u00b1\u00a037.75 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Persistent OSA was found in 56.25% of the children. Univariate regression suggests that postoperative OSA\u201018 score was associated with persistent OSA after adenotonsillectomy. Preoperative oAHI, preoperative oxygen desaturation index, pre\u2010 and postoperative OSA\u201018 scores correlated with OSA severity after adenotonsillectomy. However, in a multivariate model only the postoperative OSA\u201018 score correlated with OSA severity after adenotonsillectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although adenotonsillectomy results in a significant improvement of OSA in children with trisomy 21, more than half of the children had persistent OSA. The postoperative OSA\u201018 score was associated both with persistent OSA and OSA severity after adenotonsillectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13657","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T15:26:37Z","timestamp":1602775597000},"page":"256-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Predictors of OSA following adenotonsillectomy in children with trisomy 21"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-0737","authenticated-orcid":false,"given":"Diogo","family":"Raposo","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Prof. Doutor Fernando Fonseca Amadora Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Menezes","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Prof. Doutor 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