{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:07:57Z","timestamp":1784758077760,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study is to investigate factors that are associated with having a non\u2010localising <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective study was performed on patients that underwent parathyroid surgery performed within a single institution between 2001 and 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single tertiary centre for parathyroid surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>230 patients underwent surgery for primary hyperparathyroidism due to a solitary parathyroid adenoma and had preoperative <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Variables including age, gender, intra\u2010operative location of parathyroid adenoma, adenoma weight and pre\u2010 and postoperative calcium and parathyroid hormone levels were investigated through univariate and multivariate analysis to identify any association with having a non\u2010localising (negative) <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi scan result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analysis identified that right\u2010sided adenomas (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.038), superior adenomas (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.042) and a lower preoperative PTH level (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.034) were all individual factors associated with having a negative <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi scan result. Although the weight of the adenoma was significant on univariate analysis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.029), this was not demonstrated on multivariate analysis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.422).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Factors that were associated with having non\u2010localising <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi scan were right\u2010sided adenomas, superior adenomas and lower preoperative PTH level. Further large prospective multicentre studies are needed to further evaluate these initial findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13677","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T23:01:42Z","timestamp":1606863702000},"page":"357-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Factors related to a non\u2010localising technetium 99m sestamibi scan result during parathyroid adenoma imaging in primary hyperparathyroidism"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-4336","authenticated-orcid":false,"given":"Richard","family":"Jackson","sequence":"first","affiliation":[{"name":"Department of ENT Castlehill Hospital Cottingham 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